WK.02  Serial Crystallography Data Analysis with Cheetah and CrystFEL: Concepts and Tutorials

SOLD OUT contact: kvitale@hwi.buffalo.edu to be put on a waiting list


Nadia Zatsepin

Arizona State Univ


Edward Snell

Hauptman Woodward Medical Research Inst.


Thomas Grant

Hauptman Woodward Medical Research Inst.


Cornelius Gati




Serial femtosecond crystallography has yielded several major and unique advances in structural biology previously unattainable with conventional technologies, including the potential for sub-picosecond time-resolved crystallographic studies, probing cyclic or even non-cyclic reactions. With the construction of more than a dozen new XFELs currently under way, and the multiple recent demonstrations of SFX at synchrotrons, the potential user base is growing significantly. The development and appropriate use of new software to tackle the unique problems of SFX data analysis is vital to making SFX practicable.


The workshop will start with an introductory seminar, followed by most of the day dedicated to detailed hands-on tutorials with data sets collected at LCLS using the software suites Cheetah and CrystFEL, two of the most commonly used packages for SFX analysis. The concepts unique to SFX that we will be discussing are software independent.   


We will assume students have some basic knowledge of conventional crystallographic data analysis such as what indexing, integration, and merging are and will instead focus on the specific features of serial crystallography analysis. Practice data (from cxidb.org <http://cxidb.org> ) will be available. Students will be expected to bring laptops with appropriate software preinstalled. Students will be sent detailed information prior to the workshop. The workshop will begin at 8:30am and end at 5:00pm. Lunch will be provided.


All participants must pre-register for the workshop and submit the following fee with their meeting registration form:
Student or Post-doc -  before May 31, $100, on or after June 1, $150
Academic others - before May 31, $150, on or after June 1, $200
Corporate - before May 31,  $250, on or after June 1, $300

The workshop will begin at 9:00am and end at 5:00pm. Lunch will be provided.

Workshop fees can be waived for a limited number of students (sponsored by the National Science Foundation BioXFEL Science and Technology Center). You will need to apply for the stipend through the BioXFEL STC, by contacting Jill Szczesek at jszczesek@hwi.buffalo.edu