Workshops

 

 

All workshops will be held on Saturday, July 24, 2010, 8a.m. to 5p.m. Pre-registration is mandatory and should be indicated on your registration form.

   

 

WK1: Global Phasing Software Suite for Macromolecular Crystallography

Saturday, July 24, 2010

Northwestern Univ.

Early Registration: $135 per person, Late Registration: $170 per person

 

Gerard Bricogne, Organizer

 

The scope of the workshop will include GP programs for automated data processing, experimental phasing, and structure refinement. The lecturers are GP developers, including Clemens Vonrhein, Claus Flensburg, Oliver Smart, Thomas Womack, and Gerard Bricogne. Breakout sessions are planned to give participants the opportunity to gain hands-on experience with the software, and attendees are encouraged to bring their own data. Attendees are asked to install the software prior to the workshop, including autoPROC, SHARP/autoSHARP, BUSTER, autoBUSTER, XDS, MOSFLM, CCP4, and SHELX.

 

 

WK2: PLATON

Saturday, July 24, 2010

Sheraton Chicago Hotel & Towers

Early Registration: $140 per person, Late Registration: $175 per person

 

Lee Daniels, Organizer

 

The PLATON workshop will provide hands-on training for most of the basic operations of the PLATON suite. Attendees will be expected to have downloaded and installed the programs onto their own portable computers and to bring these computers to the workshop. Copies of the installation will also be available on site, and some sample datasets will be provided to demonstrate various features of the program. Attendees are encouraged to bring their own data sets for analysis. Confirmed speakers include the author of PLATON, Ton Spek (Utrecht University), and Max Siegler (Johns Hopkins University). Martin Lutz (Utrecht University) has been described as someone who "probably knows more about PLATON than anyone else" and will also be invited to speak. The session will be a full-day workshop, with the morning session dedicated to learning the use of the basic features of the program. The afternoon will be used to go into more detail of several features of the suite and to work through sample and user-provided data sets.

 

 

WK3: Sulfur-SAD Data Collection and Phasing

Saturday, July 24, 2010

Univ. of Illinois at Chicago

Early Registration: $120 per person; Late Registration: $150 per person

 

This workshop (lectures in the morning and hands-on exercises in the afternoon) is intended for both students and professionals interested in SAD data collection and phasing. The focus of the workshop will be on sulfur-SAD phasing mainly because it is the most demanding SAD phasing technique in terms of sample preparation, crystal mounting, data collection and data processing.

 

Morning session lecturers will cover such topics as (1) SAD theory, (2) Sample preparation, (3) Source/beamline considerations, (4) Data collection strategies, (5) Data processing theory, (6) Anomalous substructure determination and (7) Generating initial protein phases and electron density maps.


The afternoon session will focus on hands-on exercises in data reduction and sulfur-SAD phasing. Here attendees will process a set of zinc-free insulin data (51 residues, 3 disulfides, space group I213, a = 78Å) using common data reduction packages. Then, using the scaled structure factors, attendees will attempt to (1) determine the anomalous scattering substructure (insulin disulfide centroids), (2) determine the correct hand of the disulfide centroids, (3) calculate a set of initial protein phases and (4) interpret the quality of the electron density map produced.


Attendees will also work on the more demanding sulfur-SAD structure determination of ORF 1382 from Archaeoglobus fulgidus (95 amino acids, 5 sulfurs, space group P42) whose crystals only diffract to 2.65Å resolution.


All workshop attendees will receive a DVD containing lecture materials and a how-to guide for the crystallization of zinc free insulin and crystal cryoprotection protocol together with instructions for crystal mounting and data collection so that they can practice sulfur-SAD data collection and phasing at their home institution, after the workshop.


Workshop instructors
Bi-Cheng Wang, University of Georgia
John P. Rose, University of Georgia
John Chrzas, SER-CAT Advanced Photon Source, Argonne National Laboratory
Zeng-Qing Fu, SER-CAT Advanced Photon Source, Argonne National Laboratory
Bernard Santarsiero, University of Illinois at Chicago
Manfred Weiss, European Molecular Biology Laboratory, Hamburg, Germany
James Liu, Institute of Biophysics, Academia Sinica, Beijing, China

 

 

WK4: Getting the Most out of the CCP4: Suite With Particular Emphasis on Low Resolution Refinement and Model Building

Saturday, July 24, 2010

Univ. of Illinois at Chicago

Early Registration: $120 per person; Late Registration: $150 per person

 

Charles Ballard, Organizer

Speakers: Paul Emsley (COOT), Garib Mursudov (REFMAC), Stuart McNicholas (CCP4MG), Ronan Keegan (MrBUMP), Harry Powell (MOSFLM)

 

Hands-on workshop in using CCP4 for macromolecular problems, including data processing with MOSFLM, molecular replacement, model building with coot, and refinement with REFMAC. Participants are encouraged to bring their own data. Problem solving will continue at the CCP4 exhibition stand.


 

 

WK5: Crystallography: World of Wonders

Saturday, July 24, 2010

Sheraton Chicago Hotel & Towers

 

Cora Lind, Organizer, with Christine Zardecki, David Goodsell, and Claudia Rawn for Chicago Public School teachers

 

Structure - It's Everywhere!
The U.S. National Committee for Crystallography announces a crystallography education workshop offered in conjunction with the American Crystallographic Association (ACA) on July 24, 2010, at the Sheraton Chicago Hotel & Towers. This one-day workshop is designed as a continuing education opportunity for high school teachers, and will supply teachers with theoretical background and hands-on activities to design lesson and experiment plans that can be taken back to the classroom.

 

Crystallography has influenced many important areas of today's society. Its main goal is to investigate the atomic level structure of molecules and materials. Most solids have highly ordered, repetitive structures that are analyzed by diffraction methods. Structure is everywhere, and structure is important, as it determines the properties of each material. Knowledge of atomic level structure gives scientists insights into how materials function, and opportunities to tailor their properties.


Structure is used by many, but few stop to consider its roots in crystallography. The bond lengths and angles in molecular drawings used in chemistry classes are a result of crystal structure analyses. The three-dimensional pictures of proteins, enzymes, and complexes were created from crystallographic data. The external shape of mineral crystals is related to their atomic level structures. It is the goal of this workshop to give participants an appreciation of structure, and to illuminate basic crystallographic principles and how they relate to structural pictures used in science classes. Concepts will be introduced at an age-appropriate level for incorporation in K-12 teaching.


The workshop will cover both theory and hands-on exercises. We will start with basic concepts like repeating motifs, crystal systems, and mineral crystals. Some very basic structures will be chosen to construct crystallographic models with readily available materials like legos and yarn. Different types of bonding and the effect of bonding on structure and properties will be introduced.


Diffraction basics will be visualized using lasers and gratings. For high school science classes, Bragg's law, which describes where reflections are observed in the diffraction pattern, can be derived from simple trigonometric constructions.


The importance of understanding atomic level structure and the three-dimensional packing of atoms and molecules will be apparent for biological macromolecules. The protein data bank will be introduced, and tools for searching and exploring the available information will be presented. The intimate relationship between crystallography and research fields like drug design or understanding of protein function will be explained.
Teachers are encouraged to register for this one day workshop.

 

There is no fee to attend, but registration for the workshop is required.  This is separate from registration for the full meeting.  Nametags are valid for Saturday only and do no include the Opening Reception.  Materials for classroom activities and lunch will be provided. Attendees will also have the opportunity to attend the opening plenary lecture by 2009 Nobel Laureate Venkatraman Ramakrishnan at 6:15pm.

 

To register:

Please download this form and submit it to the ACA office.  You may fill out the PDF form and use the Submit button at the bottom (use Adobe Reader or Adobe Acrobat for this option).  You may also fax it to (716) 898-8695 or email it as an attachment.  


Important Deadlines

Student & Young Scientist Travel Grants:

March 31, 2010

Abstract Submission:

April 7, 2010

 

Advanced (Early) Registration:

May 31, 2010

 

Last Day for Conference Hotel $40/Night Off Deal:

April 30, 2010 

 

Last Day for Conference Hotel Rates:

June 22, 2010 

Office Information

American Crystallographic Association

P.O. Box 96 Ellicott Station

Buffalo, NY 14205-0096

Phone: (716) 898-8690

Fax: (716) 898-8695

[email protected]