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Faculty Positions
Macrocolecular X-Ray Crystallographer
Arizone State University
The Department of Chemistry and Biochemistry at ARIZONA STATE UNIVERSITY
invites applications for a full-time, state-budgeted position as
facilities manager, protein x-ray crystallography and instructional
computing resources.
A PhD in the chemical sciences or related field and expertise in protein
X-ray crystallography are required. Duties include the maintenance and
repair of in-house X-ray equipment, management of crystallographic and
instructional computing resources, and training of research personnel.
Applicants must submit a cover letter, curriculum vitae and summary of
research experience as a single electronic PDF document to xraysearch@asu.edu.
Applicants must also arrange for three letters of recommendation to be
submitted to xraysearch@asu.edu.
Cover and recommendations letters should be addressed to:
X-Ray Crystallography Search Committee
Department of Chemistry and Biochemistry
Arizona State University
PO Box 871604
Tempe, AZ 85287-1604
For additional information, please contact Dr. Rebekka Wachter at rwachter@asu.edu
Review of applications begins January 25, 2010, and will continue every
two weeks thereafter until the position is filled. A background
check is required for employment.
ASU is an EO/AA employer and is committed to excellence through
diversity. Women and minorities are encouraged to apply.
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Structural
Biology/Crystallography
Univ of Waterloo
Applications are being accepted for a tenure track position at the
Assistant or Associate Professor level in the Department of Biology,
Faculty of Science, University of Waterloo. Applicants should have a PhD
and postdoctoral experience with a research record in Macromolecular
X-ray Crystallography. Duties of the position include establishment of
an independent research program, teaching and supervision at the
undergraduate and graduate levels, and participation in the running of
the Department and University. The University has instrumentation for
macromolecular crystallography, including a Rigaku Micromax/R-Axis 4++
diffractometer system.
Inquiries and applications, consisting of a full curriculum vitae with
publication record, statement of research interest and teaching
experience, and names of three references and their contact information,
should be sent electronically to the attention: Dr. David R. Rose,
Chair, Department of Biology, University of Waterloo (sent via email to Mrs.
Gini Kennings, Chair's Secretary)
The closing date for applications will be September 1, 2010, with a
starting date on or after January 1, 2011.
All qualified candidates are encouraged to apply; however Canadian
citizens and Permanent residents will be given priority. The University
of Waterloo encourages applications from all qualified individuals,
including women, members of visible minorities, native peoples, and
persons with disabilities.
Contact:
Mrs. Gini Kennings Chair's Secretary
Dept. of Biology
University of Waterloo
Waterloo, ON N2L 3G1
CANADA
Phone: 519-888-4567 Ext. 33943
Fax: 519-746-0614
Email
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Research Associate - Bioinformatics
Medical Univ. South Carolina
The Medical University of South Carolina (www.musc.edu) seeks a highly motivated individual with expertise in bioinformatics and computational biology to be part of an interdisciplinary core informatics group interacting with a wide range of scientists
addressing basic biomedical questions in genomics, systems biology, and drug discovery.
The candidate should possess a BS, MS or PhD degree in computer science, information sciences, bioinformatics, or computational biology and have demonstrated capabilities in cyber-interface management and enablement, programming, and parallel computing systems related to biomedical-based research. The successful applicant will be part of a rapidly expanding initiative in bioinformatics at MUSC.
Apply on-line at www.jobs.musc.edu (Requisition #046497). Review of applications will begin June 30, 2010. Applications will be accepted until the position is filled and must include a cover letter, resume and at least three references.
Extramural research funding awards to MUSC in fiscal year 2009 exceeded $217 million, reflecting tremendous continued growth in the research enterprise, including most recently a National Cancer Institute (NCI)-designated cancer center, an NIH Clinical and Translational Science Award, and NSF-funded research infrastructure grants that support major regional partnerships across the State of South Carolina. Two new, ~100,000 sq ft research buildings housing programs in Drug Discovery, Cancer Genomics and Bioengineering will open in 2011.
MUSC is located in the beautiful, historic coastal city of Charleston, South Carolina (www.charlestoncvb.com ). Founded in 1824 as the South's first medical school, the Medical University of South Carolina is a publicly supported, free-standing academic
health sciences center composed of six colleges: Dental Medicine, Graduate Studies, Health Professions, Medicine, Nursing, and Pharmacy, as well as the University Hospital Authority. The institution and its affiliates employ approximately 10,000 individuals,
including more than 1,300 faculty members.
Salary is commensurate with experience. MUSC is an equal opportunity employer, supporting workplace diversity.
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Director, X-ray Crystallography Center
Emory University
Candidates for the position should have experience in the operation of an X-ray Service Facility as well as considerable experience in X-ray crystallographic techniques and experience in the operation of single crystal and powder diffraction instrumentation including the handling of air sensitive samples.
Start Date:
September 2010
Contact:
Kenneth I. Hardcastle
1515 Dickey Dr
Atlanta, GA 30322
khardca@emory.edu
phone: 404 727 6140
fax: 404 727 6586
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Industry
Positions
Scientist/Senior
Scientist - X-Ray Crystallographer in China
Crown Bioscience
Location: Beijing, China
URL: www.crownbio.com
Start Date: as soon as possible
Description: We are seeking
highly motivated x-ray crystallographer and protein scientists in our
Structural Biology Department at the level of senior Scientist or
Scientist depending on qualifications. The successful candidate will be
primarily responsible for protein crystallization and structure
determination and refinement. The work includes optimization of existing
strategies and crystallizing proteins in the presence or absence of
small molecule ligands. Experience with protein crystallization,
diffraction data collection (in house and synchrotron), structure
determination and refinement is required. Experience with high
throughput gene-to-structure work including gene cloning, gene
expression in different systems (E. coli, baculovirus, and mammalian
cells), protein purification are preferred. You are also responsible for
writing standard operation procedures, reports and reviews, presenting
seminars and interacting with clients regarding work performed, while
preparing abstracts, posters, and manuscripts for scientific meetings
and publication.
Please submit: CV
Person to contact: Max Wang
Email address: maxwang@crownbio.com
Phone number: +86-10-69719900
ext 501
Job Posted: 10/15/09
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Senior
Scientific Software Engineer
Rayonix
About the job
We are seeking a Senior Scientific Software Engineer for the design and
development of software to support state-of-the-art scientific X-ray
detectors. You will be the key contributor in new products and
services, using your science background and scientific programming
skills. You will be the core contributor in the design and development
of software for a major new instrument family, working in close
association with Dr. Michael Blum, founder and CEO of Rayonix. In
addition, you will work with Dr. Blum and scientists world-wide whose
novel research efforts require on-going development and innovation with
existing products. You will also manage and mentor other IT-related
staff.
About the company
Rayonix has an international reputation for providing the most advanced
large area X-ray detectors. These instruments are utilized in nearly
every major synchrotron across the globe, as well as numerous academic
and industrial labs. Our detectors are being used to push forward the
frontiers of scientific knowledge in a myriad of different applications,
including macromolecular crystallography, small angle X-ray scattering
(SAXS), polymers, surface science, and materials science. We have built
our reputation on the excellent data quality, solid reliability, ease of
use of our instruments, and extraordinary support for our
researcher-customers.
While our work is quite complex, our work-life is very simple: We are
casual, fun, flexible, hard working, and committed to being the very
best at what we do.
Qualifications:
Candidates considered first for this job will have:
- At least three years of scientific
programming using C and C++, Linux/Unix, and more recent applications of
object-oriented languages (Python, Perl, etc.)
- Broad product development capability: code architecture, project
design, programming, documentation and QA
- Experience with GUI development tools
- Experience with instrument and machine control issues, database
structures, and client server applications; experience with scientific
instrumentation is preferred
- Excellent written and oral communications
- An advanced degree in physics, engineering, biology, or
crystallography would be advantageous
- Experience with scientific instrumentation is desirable; experience
with X-ray detectors or other CCD (charge-coupled device) applications
even better.
Rayonix is most decidedly an equal opportunity employer and qualified
candidates with diverse backgrounds are strongly encouraged to apply.
To apply, please go to: http://tinyurl.com/Rayonix-Jobs.
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Protein
Crystallographer
ArQule, Inc.
ArQule has established a cutting-edge kinase discover platform called
AKIPTM (ArQule Kinase Inhibitor Discovery) for the discovery
of kinase inhibitors that are not classically ATP competitive. ArQule
has demonstrated the validity of the approach in its internal discovery
portfolio and is also leveraging it to establish research collaborations
such as the one with Daiichi Sankyo.
This technology utilizes a powerful in silico structure-based drug
design approach driven by an in-depth structural biology understanding
of the precise mechanism of inhibition of these drug-like molecules.
The newly created Structural Biology Group at ArQule is looking to
strengthen its team by the addition of a Protein Crystallographer who
will be responsible for advancing this new technology by designing and
employing a wide variety of biophysical and biochemical methods to
extensively study these kinase inhibitors.
The suitable candidate will join an experienced and successful
multi-disciplinary drug discovery team with a mission to fully develop
and utilize this new methodology to bring next-generation kinase
inhibitors to the clinic.
Brief Purpose of the job:
Determine structure-function properties of small molecule-protein
interactions at ArQule
Job Responsibilities:
• Design, expression, purification and characterization of proteins
using eukaryotic and microbial expression systems.
• Generate supplies of proteins required for compound target
crystallography
• Crystallize, collect x-ray data, solve & refine protein
coordinates
• Represent discipline in structure based drug discovery &
development teams
• Maintain day-to-day contact with external suppliers of research
materials or CROs engaged in supplying custom materials such as cell
paste for purification
• Develop and implement protein-ligand interaction assays
• Conduct enzyme kinetics assays
Education: PhD or equivalent in structural biology, biophysics, or
related discipline and preferably 2-5 or more years experience in
protein X-ray crystallography and structure based drug design in a
pharmaceutical or biotechnology environment.
Experience:
• Extensive experience in basic molecular cloning techniques including
PCR and primer design as well as plasmid purification, and restriction
mapping.
• Experience with bioinformatics platform such as DNA and protein
sequence analyses, multiple sequence alignments, BLAST, etc.
• Experience in SDS-PAGE including Western-blot analyses.
• Hands-on experience in recombinant protein expression in E. coli,
insect cells and mammalian cells.
• Hands-on experience in protein purification using various tag systems
and wide range of liquid chromatography methodology.
• Protein crystallization and structure determination by X-ray
diffraction.
• Experience in determining protein-ligand interactions and enzyme
kinetics
Work Habits:
The ideal candidate must be comfortable working in a fast-paced,
interdisciplinary environment. He/she must be a team player and has
ability to work equally with biologists and chemists. He/she will gain
exposure to all aspects of drug discovery and development and must be
able to multi-task multiple responsibilities in multiple areas. In
addition, written and verbal communication to scientists and non-experts
will also be essential for success. The successful candidate will show
evidence of sustained productivity and independent contributions in
science.
Contact: Human Development
ctyre@arqule.com
ArQule, Inc.
19 Presidential Way
Woburn, MA 01801
Phone: (781) 994-0330
Fax: (781) 994-0681
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Senior
Director, Structural Biology
Takeda San Diego
Objectives:
Directs, develops and integrates the Company's Structural Biology
resources to ensure timely achievement of major goals. Oversees and
provides direction for the Molecular Biology, Crystallography, and
Protein Chemistry sub-groups. Provides deep expertise and strategic
leadership in X-ray crystallography, and across structure based drug
design programs in oncology, inflammation and metabolic diseases.
Invents and advances drug candidate compounds towards preclinical and
clinical development.
Accountabilities
• Directs the management and research activities of TSD Structural
Biology departments to enhance the Company's IND success rates,
particularly in the oncology, inflammation, and metabolic diseases
therapeutic areas..
• Acts as a thought leader in crystallography and structure-based
• Co-leads TSD cross-functional drug discovery programs to achieve
compelling target product profiles based on scientific, clinical,
regulatory, and commercial rationales
• Plays an integral role in TSD drug discovery target selection and
portfolio management both as a member of the TSD Research Committee and
in inter-site Takeda forums in the US and Japan.
• Sets annual site-level and multi-year strategic plans, and engages in
international corporate strategic planning to fulfill TSD's mission as a
Takeda IND engine.
• Directs and controls the activities of one or more
functional/technical areas including Molecular Biology, Crystallography,
& Protein Chemistry. Responsible for the direct line management of
the department team leaders (up to Director level), and for their
research and career development
• Effectively communications multiple dimensions of Company's science
and business strategies and establishes productive relationships with
outside groups, including major collaborations.
• Collaborates with senior management to manage company operations and
set company-wide policies
• Budgetary responsibility for functional areas. Summarizes and
presents R&D project status, budget, and issues/highlights to senior
management and project leaders/teams. Ensures budget requirements are
met.
• Teaches, advises, and leads direct and indirect reports in an
inspirational fashion, to accomplish key group and corporate objectives
Education, Experience, Knowledge And Skills:
• Ph.D. in crystallography, or a related discipline, and a minimum of 12
years industry experience; OR
• MS in chemistry, or related discipline and a minimum of 14 years of
industry experience; OR
• BS in chemistry, or related discipline and a minimum of 17 years of
industry experience
• Recognized internationally as an expert in crystallography and
structure-based drug design
• Track-record of expertise in X-ray crystallography of soluble and
membrane-associated proteins and in using crystallographic data to
invent potential novel medicines
• Inspirational leadership skills with proven experience in successfully
managing large projects and maximizing the performance of large groups
of scientists
• Track-record of expertise in structure based drug discovery, including
biochemistry, biology, efficacy and Pharmacodynamic/biomarker models,
and toxicology
• Extensive knowledge of current drug discovery & development
processes worldwide with an emphasis on oncology, inflammation and
metabolic disease areas
• Clear record of accomplishment (e.g. publications, patents,
presentations) including evidence of leadership in delivering one or
more internally discovered compounds into clinical development
• Exceptional interpersonal, collaborative and team-building skills
• Outstanding written and oral communication skills
Physical Demands:
• Potential exposure to hazardous/toxic/dangerous chemicals
• Manual/physical dexterity required to operate basic office equipment
(i.e. computers, printers, phones, photocopiers, etc.), and carrying,
handling and reaching for objects.
• Prolonged standing and/or sitting.
Travel Requirements:
• Ability to drive or fly to various meetings or client sites, including
overnight trips.
• International travel required, including some weekends
• Requires approximately 15 % travel.
Submit your resume and start a quality career with Takeda!
We are an equal opportunity employer.
www.takedasd.com
www.tpna.com
No Phone Calls or Recruiters Please.
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