Job Seekers: Find available employment positions in crystallography and related disciplins. Look for jobs based upon location, job description, hiring company.
Employers: To post an open position, please contact Marcia Colquhoun at marcia@hwi.buffalo.edu. Please be sure to let us know when positions have been filled so we can keep this board as up-to-date as possible.
Browse Job Categories:
Post-Doctoral Research Fellowships (academic and industrial)
Industrial and Commercial Positions (permanent)
Other Positions
Faculty & Staff Positions
| Date Posted |
Job Title | Institution Name |
Location |
| Nov. 2009 |
X-ray Facility Manager |
University of Pittsburgh School of Medicine |
Pittsburgh, PA, USA |
| 12/14/09 | Macromolecular X-ray Crystallographer | Arizona State University |
Tempe, AZ, USA |
Post-Doctoral Positions
| Date Posted |
Job Title | Institution Name |
Location |
| 11/3/09 |
Postdoctoral Research Associate | Purdue University |
West Lafayette, IN, USA |
| 10/28/09 |
Research Investigator | Bristol-Myers Squibb |
Wallingford, CT, USA |
| Nov. 2009 | Research Fellow Opportunity | Kelly Scientific Resources | Ann Arbor, MI, USA |
| Nov. 2009 | Postdoctoral Research Associates | Cold Spring Laboratory |
Cold Spring Harbor, NY, USA |
| Nov. 2009 | Postdoctoral Positions |
Vanderbilt University |
Nashville, TN, USA |
| 10/27/09 | Postdoctoral Fellow | Cold Spring Laboratory | Cold Spring Harbor, NY, USA |
| 10/19/09 | Postdoctoral Associate | Cornell University | Cornell, NY, USA |
| 10/15/09 | NIH Funded Post-Doctoral Fellow in RNA Structure & Function | The University of Rochester Medical Center | Rochester, NY, USA |
| 9/28/09 | Post-Doctoral Fellow | St. Jude Children's Research Hospital | Memphis, TN, USA |
| 9/23/09 | Postdoc Position in Structural Biology & Biochemistry | University of California | San Diego, CA, USA |
| 9/23/09 | Research Associate | Stanford Synchrotron Radiation Lightsource | Menlo Park, CA, USA |
| 09/17/09 | Postdoctoral Fellow | University of Minnesota | Minneapolis, MN, USA |
| 09/08/09 | Postdoctoral Researcher: Protein Crystallography and Electron Cryo-Microscopy | University of Kansas | Lawrence, KS, USA |
| 01/04/10 | Postdoctoral Postition in Protein Crystallography |
Baylor College of Medicine |
Houston, TX, USA |
| 01/05/09 | Postdoctoral Position in Solid State Organic Chemistry |
Kansas State University |
Manhattan, KS, USA |
| 01/08/10 | Postdoctoral Research Associate | Naval Research Laboratory | Washington, DC, USA |
| 02/08/10 | Postdoctoral Associate | Cornell University | Ithaca, NY, USA |
| 02/18/10 |
Postdoctoral Research Fellow | University of Wisconsin | Madison, WI, USA |
| 02/25/10 |
Postdoctoral Associate |
Genzyme Corporation |
Waltham, MA, USA |
| 03/01/10 |
Post-doctoral Position in Structural Enzymology |
Univ of Wisconsin |
Milwaukee, WI, USA |
| 03/09/10 | Postdoctoral Associate | Mineralogisch-Petrographisches Inst |
Hamburg, Germany |
| 03/09/10 | Postdoctoral Associate |
Hauptman Woodward Medical Research Institute |
Buffalo, NY, USA |
Industry & Commercial Positions
| Date Posted |
Job Title | Company Name |
Location |
| 10/28/09 |
Research Investigator | Bristol-Myers Squibb | Wallingford, CT, USA |
| 10/15/09 |
Scientist/Senior Scientist |
Crown Bioscience |
Beijing, China |
| 01/21/10 | Senior Scientific Software Engineer | Rayonix |
Evanston, IL, USA |
| 02/11/10 |
Marketing Director |
Rigaku Automation, Inc |
Carlsbad, CA, USA |
| Date Posted |
Job Title | Institution Name |
Location |
| 01/25/10 | Macromolecular X-ray Crystallographer |
Xtal BioStructures, Inc. |
Natick, MA |
| 02/26/10 | HHMI Interdisciplinary Science Fellow | Vassar College | Poughkeepsie, NY, USA |
University of Pittsburgh School of Medicine
We are seeking an experienced person to manage our macromolecular X-ray crystallography facility and report directly to the Director (Joanne I. Yeh, Ph.D.) and co-Director (William Furey, Ph.D.). The successful candidate will train personnel in the use of X-ray crystallographic equipment, software, and robotics providing scientific and technical guidance as needed, as well as coordinate service issues with the equipment vendors. The facility manager will also coordinate scheduling and allocation of general users time and maintain usage logs, with the guidance of the Director & co-Director. The facility houses two high intensity FR-E generators with four detectors, including two Saturn 944 CCDs, a RAXIS IV++ image plate detector, and a RAXIS HTC image plate detector, along with a crystallization robot and imaging systems. An ACTOR robot is present on one system for automatic mounting and screening of crystals. All systems are equipped with VariMax optics to provide high intensity and highly focused X-ray beams, and utilize X-stream 2000 cryogenic systems. The successful candidate will also have opportunities to work in a multi-disciplinary team on structural biology projects related to the Pittsburgh Center for HIV-Protein Interactions. Experience with handling, cryo-cooling, and manipulation of macromolecular crystals and in structure determination and refinement is required. Prior X-ray facilities management or equipment maintenance experience is a plus. Applicants should have a PhD or equivalent experience and salary is to be commensurate with experience.
Interested applicants should send their CV, the names of 3 references, and have letters sent to either:
Dr. Joanne I. Yeh
Department of Structural Biology
University of Pittsburgh School of Medicine
3501 Fifth Avenue
1036 BST3
Pittsburgh, PA 15260
Office: 412-648-9027
E-mail: jiyeh@pitt.edu
or
Dr. William Furey
Dept. of Pharmacology & Chemical Biology
University of Pittsburgh School of Medicine
Lothrop Street 1340W BSTWR
Pittsburgh, PA 15261
Tel: 412-683-9718
E-mail: fureyw@pitt.edu
Macrocolecular X-Ray Crystallographer
Arizone State University
The Department of Chemistry and Biochemistry at ARIZONA STATE UNIVERSITY invites applications for a full-time, state-budgeted position as facilities manager, protein x-ray crystallography and instructional computing resources.
A PhD in the chemical sciences or related field and expertise in protein X-ray crystallography are required. Duties include the maintenance and repair of in-house X-ray equipment, management of crystallographic and instructional computing resources, and training of research personnel.
Applicants must submit a cover letter, curriculum vitae and summary of research experience as a single electronic PDF document to xraysearch@asu.edu. Applicants must also arrange for three letters of recommendation to be submitted to xraysearch@asu.edu.
Cover and recommendations letters should be addressed to:
X-Ray Crystallography Search Committee
Department of Chemistry and Biochemistry
Arizona State University
PO Box 871604
Tempe, AZ 85287-1604
For additional information, please contact Dr. Rebekka Wachter at rwachter@asu.edu
Review of applications begins January 25, 2010, and will continue every two weeks thereafter until the position is filled. A background check is required for employment.
ASU is an EO/AA employer and is committed to excellence through diversity. Women and minorities are encouraged to apply.
Postdoctoral Research Associate
Purdue University
Department: Biological Sciences
Location: West Lafayette, IN, USA
Start Date: Immediate
Duration: 1 year; extension possible
Description: Postdoctoral Position in Structural Biology of Membrane Proteins. A postdoctoral is sought to work on structure-function of one or more integral membrane proteins or protein complexes in a multi-investigator multi-institutional project centered in the structural biology group of the Dept. of Biological Sciences, Purdue University. The major expertise(s) that the person should bring to the projects include x-ray crystallography and/or structure analysis by single particle cryo-electron microscopy. Experience in membrane protein purification is relevant. The five laboratories at Purdue involved in this project will move to a new building at the end of this year. Interested parties should respond, including a CV and the names/addresses of 3 references, to W. A. Cramer (waclab@purdue.edu) by November 23, 2009.
Please submit: CV; 3 letters of reference
Person to contact: W. A. Cramer
Surface mail address: 915 West State St., Lilly Hall, W. Lafayette, IN 47907
Email address: waclab@purdue.edu
Phone number: 765-494-4956
Fax number: 765-496-1189
Job Posted: 11/03/09
Research Investigator
Bristol-Myers Squibb
Department: Analytical Research and Development
Location: Wallingford, CT 06492
Start Date: ASAP
Description: The successful candidate will work in a state of the art Solid State Chemistry laboratory for X-ray single crystal structure determination, powder X-ray diffraction and solid-state characterization of drug bulks. As a member of a highly effective team, they will provide crystallography/solid-state chemistry collaboration in support of drug discovery and preclinical compound optimization, as well as product development programs. The candidate major responsibilities will include: 1. Preparation of single crystals and structure determination of discovery lead compounds and intermediates; 2. Solid-state analysis of bulks in support of API crystallization efforts and pre-formulation characterization; 3. Routine maintenance of the lab hardware and update of the application software; 4. Independent planning and execution of R&D projects, effective oral communication, timely written documentation, and data base entry of results. The candidate will also have the opportunity to develop cross site interactions with process chemists and pharmaceutical scientists and participate in the final form selection, salt and polymorph screening of Active Pharmaceutical Ingredients, API. A PhD, MS (4 years of experience) or BS (7 years of experience) with background in chemistry or engineering is sought. The candidate should have hands-on experience with chemical crystallography, including X-ray diffraction data collection/processing/analysis and structure solution/refinement. Strong experience in crystallization of organic/inorganic materials and preparation of crystalline salts is also required. A working knowledge of physical characterization techniques (e.g. thermal analysis, microscopy, sorption analysis) for chemical/pharmaceutical bulk solids is a plus. Independence and creativity, strong organizational and written/verbal communication skills as well as a demonstrated ability to work within an interdisciplinary research team are essential.
Please submit: CV, coverletter, names of 3 references
Person to contact: Dr. Qi Gao
Email address: qi.gao@bms.com
Phone number: 732-227-6063
Job Posted: 10/28/09
Postdoctoral Research Associate
Cold Spring Laboratory
Applications are invited for postdoctoral positions at Cold Spring Harbor Laboratory (CSHL) from highly enthusiastic individuals with strong interest in utilizing structural, electrophysiological, and biochemical approaches to study fundamental problems in ion and substrate transports across the membrane. Our goal is to understand molecular basis for synaptic transmission and neurological disorders and diseases. We use x-ray crystallography to obtain atomic structures of target membrane/glyco proteins and test structure-based functional hypotheses by various techniques including electrophysiology, analytical centrifugation, and fluorescence assay. We are equipped with a state-of-the-art facility to conduct membrane/glyco protein crystallography and functional studies including a high-throughput protein screening system, an automated crystallization screening device, a recently updated home x-ray source, electrophysiology rigs, and other setups such as isothermal titration colorimetry device. CSHL is also located within 30 min driving distance from the National Synchrotron Light Source at Brookhaven National Laboratory. Most importantly, a highly collaborative environment at CSHL provides a unique opportunity for postdocs to interact with scientists from various fields including cancer biology, neuroscience, and plant biology. Candidates must hold (or soon expect to hold) PhD in biochemistry, molecular biology, biophysics or related fields. Strong background in molecular biology, biochemistry, large-scale protein expression in eukaryotic and prokaryotic cells, and purification of membrane/glyco proteins is desired. Experience in x-ray crystallography or electrophysiology is desirable but not necessary. For more information, please check the laboratory website (http://www.cshl.edu/public/SCIENCE/furukawa.html) and contact me via email. Please send CV, a summary of research experience and interest, and three references to Hiro Furukawa by email at furukawa@cshl.edu
Vanderbilt University
Two postdoctoral positions funded by US NIH grants are available immediately to work on structural studies of native and chemically modified nucleic acids, protein-nucleic acid interactions or the KaiABC cyanobacterial circadian clock. An overview of current projects in our laboratory can be found at: http://structbio.vanderbilt.edu/~eglim/
For recent publications in the areas of DNA, RNA and protein-nucleic acid interactions, please see: J. Am. Chem. Soc. 2009, 131, p12548; J. Biol. Chem. 2009, 284, p22467; Chem. Comm., 2009, p2017; RNA 2008, 14, p2125; Cell Cycle 2008, 7, p2562; J. Biol. Chem. 2007, 282, p36421; Nucleic Acids Res. 2007, 35, p6424; Annu. Rev. Biophys. Biomol. Struct. 2007, 36, p281; Acc. Chem. Res. 2007, 40, p197; J. Am. Chem. Soc. 2006, 128, p10847. For recent publications focusing on the structure/function of the KaiABC clock, please see: Science 2008, 322, p697; EMBO J. 2008, 27, p1767; PLoS Biol. 2007, 5, e93; EMBO J. 2006, 25, p2017; Proc. Natl. Acad. Sci. USA 2004, 101, p13933; Nature Struct. Molec. Biol. 2004, 11, p584; Mol. Cell 2004, 15, p375.
All crystallographic data collections are being conducted at the Advanced Photon Source, Argonne National Laboratory, to which we have extensive access via the Life Sciences CAT at sector 21. Candidates must have a recent Ph.D. and a strong background in chemistry or biochemistry as well as a basic knowledge of X-ray crystallography.
Please e-mail your curriculum vitae and the names of three references to: Prof. Martin Egli, Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA. E-MAIL: martin.egli@vanderbilt.edu
Research Fellow Opportunity
Kelly Scientific
Kelly Scientific has an immediate direct hire opportunity for a research fellow to join a laboratory in Ann Arbor, MI. The research projects involve the study of proteins using x-ray crystallography as well as biochemical, biophysics, and chemical genomics techniques. The research is focused on a number of synaptic adhesion molecules known to play a role in several neuro-psychiatric disorders and on a transcription factor that mediates neuro-adaptive and behavioral changes following chronic drug abuse.
Experience techniques needed include, but not limited to: macromolecular crystallization, purifying proteins, protein gel electrophoresis, expressing recombinant proteins, DNA gel electrophoresis, standard cloning techniques, and growing bacterial cultures and insect cell cultures.
Qualifications include a PhD in life sciences earned within the past 3 years. Relevant experience in the study of macromolecular crystallography is highly desirable. Good written and oral communication skills are essential. Interested candidates should e-mail their CV and 3 references to Mamie_Denton@kellyscientific.com.
Mamie Denton
Senior Scientific Recruiter
Kelly Scientific Resources
248-848-9360
248-848-9315 (fax)
www.kellyscientific.com
Postdoctoral Fellow
Cold Spring Harbor Laboratory
Location: New York
Description: Applications are invited for postdoctoral positions at Cold Spring Harbor Laboratory (CSHL) from highly enthusiastic individuals with strong interest in utilizing structural, electrophysiological, and biochemical approaches to study fundamental problems in ion and substrate transports across the membrane. Our goal is to understand molecular basis for synaptic transmission and neurological disorders and diseases. We use x-ray crystallography to obtain atomic structures of target membrane/glyco proteins and test structure-based functional hypotheses by various techniques including electrophysiology, analytical centrifugation, and fluorescence assay. We are equipped with a state-of-the-art facility to conduct membrane/glyco protein crystallography and functional studies including a high-throughput protein screening system, an automated crystallization screening device, a recently updated home x-ray source, electrophysiology rigs, and other setups such as isothermal titration colorimetry device. CSHL is also located within 30 min driving distance from the National Synchrotron Light Source at Brookhaven National Laboratory. Most importantly, a highly collaborative environment at CSHL provides a unique opportunity for postdocs to interact with scientists from various fields including cancer biology, neuroscience, and plant biology. Candidates must hold (or soon expect to hold) PhD in biochemistry, molecular biology, biophysics or related fields. Strong background in molecular biology, biochemistry, large-scale protein expression in eukaryotic and prokaryotic cells, and purification of membrane/glyco proteins is desired. Experience in x-ray crystallography or electrophysiology is desirable but not necessary. For more information, please check the laboratory website (http://www.cshl.edu/public/SCIENCE/furukawa.html) or contact me via email. Please send CV, a summary of research experience and interest, and three references to Hiro Furukawa by email at furukawa@cshl.edu
Please submit: CV, Brief description of research interest, 3 references
Person to contact: Hiro Furukawa
Surface mail address: 1 Bungtown Rd., Cold Spring Harbor, NY 11724
Email address: furukawa@cshl.edu
Phone number: 516-367-8872
Fax number: 516-367-8873
Job Posted: 10/27/09
Postdoctoral Associate
Cornell University
Department: MacCHESS
Location: Ithaca, NY
URL: search-lepp@cornell.edu
Description: Post-doctoral Associate - Biological Small-Angle Solution Scattering Cornell High-Energy Synchrotron Source The Macromolecular Diffraction Facility of the Cornell High-Energy Synchrotron Source (MacCHESS) has an opening for a post-doctoral associate. Applicants should have a Ph.D. degree in a field relevant to structural biology. Preference will be given to those with experience in x-ray solution scattering on biological systems (SAXS and WAXS). The successful candidate will be expected to collaborate with visiting research groups collecting data at MacCHESS. Activities will include applying state-of-the art algorithms to BioSAXS data, modeling macromolecular complexes, or studying conformationally- variable regions of proteins. Experience in developing hardware and software for automation including microfluidics is also desirable. Located on an ivy-league university campus in picturesque upstate New York, the Cornell High-Energy Synchrotron Source (CHESS) serves a world-wide user base of structural biologists, chemists, physicists, and engineers. MacCHESS is an NIH-supported National Resource providing support for structural biology at CHESS. MacCHESS is a heavily team-oriented environment. Good clear communication skills are a must, including fluency in the English language. This position is a 1-year appointment, renewable for up to 3 years total, contingent upon availability of funds and employee performance. Please provide an application and arrange to have at least three letters of reference sent to: Dr. Marian Szebenyi, Chair Postdoctoral Associate Search Committee Newman Lab Cornell University Ithaca, NY 14853 USA Applications should include a cover letter, curriculum vita, a publication list, and a detailed summary of research experience and interests. Electronic submissions and inquiries may be addressed to search-lepp@cornell.edu. Deadline for application is November 15, 2009. Starting date is negotiable. Cornell is an equal opportunity employer.
Phone number: 607-255-4952
Fax number: 607-254-4552
Job Posted: 10/19/09
NIH Funded Post-Doctoral Fellow in RNA Structure & Function
The University of Rochester Medical Center
Department: Department of Biochemistry & Biophysics
Location: Rochester, New York
URL: dbb.urmc.rochester.edu/labs/wedekind/Site/Wedekind_Home.html
Start Date: immediately
Duration: 1-2 year or more
Description: The University of Rochester Medical Center Department of Biochemistry & Biophysics Rochester, New York, USA An NIH funded post-doctoral position is available immediately to investigate the mechanisms of action of riboswitches and ribozymes. Primary experimental methods include X-ray crystallography, computation refinement, single-turnover kinetics, small angle X-ray scattering (SAXS), synthetic organic chemistry, protein purification, dynamic light scattering, and molecular biology. Qualified candidates must hold a Ph.D. in chemistry, biochemistry or a related field. Prior experience with X-ray crystallography is preferred. Post-doctoral fellows will have an opportunity to work with other trainees and staff members in a modern research lab with excellent equipment and resources. Travel opportunities are also available for data collection and to present scientific findings at meetings. For additional information please send a curriculum vitae and the names of three references to Prof. Joseph Wedekind (joseph.wedekind@rochester.edu).
Please submit: cv, names of three references
Person to contact: Joseph Wedekind
Surface mail address: 601 Elmwood Avenue, Box 712, Dept. Biochemistry & Biophysics
Email address: joseph.wedekind@rochester.edu
Phone number: (585) 273-4516
Fax number: (585) 275-6007
Job Posted: 10/15/09
Post-Doctoral Fellow
St. Jude Children's Research Hospital
Department: Structural Biology
Location: Memphis, TN
Start Date: immediately
Description: A post-doctoral position in Structural Biology at St. Jude Children's Research Hospital is available for highly motivated applicants to study the structure and function of replication proteins and their interaction with DNA. This position is available for applicants with a strong interest in protein crystallography and structural biology. Applicants should have recent PhD experience in biochemistry, molecular biology, crystallography, or a related field. The Structural Biology Department at St. Jude is highly interactive and has state-of-the-art facilities for structural studies, including shared synchrotron time. To apply, please send a cover letter, CV with list of publications, and 3 references.
Please submit: cover letter, CV with list of publications, and 3 references
Person to contact: Eric Enemark
Surface mail address: Department of Structural Biology, St. Jude Children's Research Hospital, Mail Stop 311, 262 Danny Thomas Place, Memphis, TN 38105
Email address: Eric.Enemark@stjude.org
Job Posted: 09/28/09
Postdoc Position in Structural Biology & Biochemistry
University of California San Diego
Department: School of Pharmacy
Location: La Jolla
Start Date: Jan 2010
Description: Postdoc Job Description: A full-time postdoctoral position is available at UC San Diego. We are looking for a highly motivated postdoctoral research fellow to join our laboratory. We are interested in structure-function studies of protein complexes involved in DNA repair process using a combination of x-ray crystallography, biochemical, and biophysical techniques. Qualifications: Successful candidates should have received a Ph.D. degree in structural biology, biophysics, biochemistry, chemistry, or related discipline. Applicants with experience in cloning and expression of recombinant protein in bacterial, yeast or insect cell systems, large-scale protein purification, macromolecular crystallization and structure determination are preferred. Applicants with a strong background in protein and nucleic acids biochemistry are also encouraged to apply. Good written and oral communication skills are essential. Procedure to Apply: Please send your CV, including contact information of 3 references (address, phone, and email) and list of your experimental expertise to Dong Wang, PhD. dongwang@stanford.edu.
Please submit: CV, including contact information of 3 references (address, phone, and email) and list of your experimental expertise
Person to contact: Dong Wang, PhD.
Email address: dongwang@stanford.edu
Job Posted: 09/23/09
Research Associate
Stanford Synchrotron Radiation Lightsource
Location: SLAC National Accelerator Lab
URL: www-ssrl.slac.stanford.edu/
Start Date: ASAP
Description: The Stanford Synchrotron Radiation Lightsource (SSRL) has an opening for a Research Associate to help support our materials sciences small angle X-ray scattering program. This position has a component (roughly 50%) that involves beam line development at SSRL and a part (remaining 50%) involving SAXS related materials science. The facility part will involve instrument development at the SSRL materials sciences SAXS beam line (1-4). This will involve rebuilding much of the in-hutch beam line components (e.g., slits, flight paths, sample stages, etc.). There will also be some development of sample environments such as furnaces and an in-vacuum, grazing incidence capability. The science part of this position is somewhat flexible but will involve studies of complex materials using SAXS and related techniques (e.g., diffraction). It is likely that some of this will include collaborative studies with investigators at universities and national labs. Qualifications: a Ph.D. in a physical science. Experience with synchrotron small angle X-ray and/or neutron scattering. Good interpersonal skills. Some experience with instrumentation design and development and computer-instrument interfacing is desirable.
Please submit: CV
Person to contact: Mike Toney
Email address: mftoney@slac.stanford.edu
Postdoctoral Fellow
University of Minnesota
Department: Biochemistry, Molecular Biology, and Biophysics
Location: Minneapolis, MN
URL: www.cbs.umn.edu/BMBB/faculty/Aihara.H.shtml
Start Date: January, 2010
Duration: 2 years
Description: A postdoctoral position will be open in January 2010 to conduct crystallographic studies of protein-DNA complexes. Our laboratory studies structure and function of various DNA-processing enzymes primarily using x-ray crystallography. Current research projects include retroviral integrases, tyrosine family of site-specific recombinases, and Holliday-junction resolvases. Successful candidate should have research experience (and Ph.D.) in biochemistry, biophysics, or similar disciplines. Prior experience with x-ray crystallography or other structural biology techniques is preferred. The University of Minnesota at Twin Cities offers superb research environment with state of the art x-ray diffraction and robotic crystallization facilities.
Please submit: CV & contact info of 3 references
Person to contact: Hideki Aihara
Surface mail address: 6-155 Jackson Hall, 321 Church Street S.E. Minneapolis, MN 55455
Email address: aihar001@umn.edu
Phone number: 612-624-1491
Job Posted: 09/17/09
Postdoctoral Researcher: Protein Crystallography and Electron Cryo-Microscopy
University of Kansas
Department: Department of Molecular Biosciences
Location: 1200 Sunnyside Ave., Lawrence, KS 66045
Start Date: Immediately
Duration: Up to 2 years, extensible
Description: An NIH-funded postdoctoral position is immediately available for a highly motivated individual with a strong interest in structure and function of macromolecular complexes in the laboratory of Dr. Liang Tang at the Department of Molecular Biosciences, University of Kansas (http://www.molecularbiosciences.ku.edu/faculty/tang.html). The projects include structural studies on protein complexes in the Type III secretion system and signal transduction in pathogenic bacteria by means of X-ray crystallography and electron cryo-microscopy. Multiple protein crystals are available and need to be optimized. The laboratory has easy access to a Rigaku RU-H3RHB X-ray generator with an R-axis IV++ imaging plate system and a 200kV FEI transmission electron microscope equipped with field emission gun both located in campus, and has regular access to synchrotron radiation beamlines. The position is funded up to two years, and may be extended dependent on performance and availability of funding. This position requires a Ph.D. in biochemistry or a related field, with a strong background in protein crystallography. For more information and to apply, go to: https://jobs.ku.edu and search with the job number 00004831. Review of applications has begun and will continue until the position is filled. EO/AA Employer.
Please submit: CV, 3 references, cover letter
Person to contact: Dr. Liang Tang
Surface mail address: Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Ave., Lawrence, KS 66045
Email address: tangl@ku.edu
Phone number: 785-864-5838
Fax number: 785-864-5294
Job Posted: 09/08/09
Postdoctoral Position in Protein Crystallography
Baylor College of Medicine
A Postdoctoral position is available immediately to determine the three-dimensional crystal structure of protein complexes. A recent Ph.D. (0-2 years) in biochemistry, chemistry, or a closely related field is required. The ideal applicant must be highly self-motivated with excellent communication skills, and must have demonstrated experience (i.e. relevant publications) with macromolecular X-ray crystallography using MIR/MAD. Experience with gene cloning, site-directed mutagenesis, protein purification and crystallization is desirable. Salary will be commensurate with experience and is in addition to a generous fringe benefit package.
To apply, please send your current CV including a brief description of research interests and accomplishments, and the names and addresses of three referees to:
Dr. Francis Tsai, Associate Professor
Dept. of Biochemistry and Molecular Biology, and Molecular and Cellular Biology
Baylor College of Medicine
One Baylor Plaza MS:BCM125
Houston, TX 77030
e-mail: ftsai@bcm.tmc.edu
Baylor College of Medicine is an Equal Opportunity Employer.
Postdoctoral Position in Solid State Organic Chemistry
State University of Kansas
A postdoctoral position in solid state organic chemistry is available immediately for studies of ferroelastic and ferroelectric domain switching, crystal growth, crystallography, organic synthesis and molecular recognition phenomena in organic inclusion compounds and related materials. This position requires a strong background in solid-state organic chemistry; the project will focus on the design, synthesis and characterization of new organic ferroelastic and ferroelectric materials. The ideal applicant would have extensive experience in the area of crystallography, materials chemistry and organic synthesis. Duration of each position would be for one year with the possibility of extension to two years. Salary will be commensurate with experience and background. Along with a cover letter, send a CV and the names and addresses of three references to:
Prof. Mark D. Hollingsworth
Chemistry Dept, 213 CBC Building
Kansas State University
Manhattan, KS 66506-0401;
ph.: 785-532-2727
fax: 785-532-6666
e-mail: mdholl@ksu.edu
Review of applications will commence Feb. 1, 2010, but the search will be extended until a suitable applicant is of Regents policy, a background check is required. Kansas State University is an Equal Opportunity Employer, and it actively seeks diversity among its employees.
Postdoctoral Research Associate
Naval Research Laboratory
Department: Center for Biomolecular Science and Engineering
Location: Washington, DC, USA
Start Date: Immediate
Duration: 2 years; extension possible
Description: The crystallography group in the Center for Biomolecular Science and Engineering (CBMSE) is currently seeking a candidate for a Postdoctoral Fellowship to work on structural studies of single-domain antibodies. The major expertise(s) that the person should bring to the projects include x-ray crystallography and crystallization of macro-molecules. The successful candidate must have a demonstrated ability to independently conduct structural studies on macro-molecules. U.S. citizenship or permanent resident status is required at time of application. The stipend level is $69,764 annually. Travel and relocation expenses are paid, with limited funds available for professional travel if approved by the Laboratory. Interested parties should respond, including a CV and the names/addresses of 3 references, to J. R. Deschamps (deschamps@nrl.navy.mil).
Please submit: CV; 3 letters of reference
Person to contact: J. R. Deschamps
Surface mail address: 915 West State St., Lilly Hall, W. Lafayette, IN 47907
Email address: deschamps@nrl.navy.mil
Phone number: 202-767-0656
Postdoctoral Associate
Cornell University
Department: Physics Department
Location: Ithaca, NY USA
Start date: Immediate through June 2010
Duration: 1+1 years; extension possible.
Description:
Our group studies the physics of cryopreservation of protein solutions, protein crystals and other biological materials, and implications for the determination of protein structures by X-ray crystallography. We want to understand what happens to water and protein when they are cooled in solution, inside crystals and inside cells; and how factors including cryoprotectants and cooling rates affect ice nucleation and growth and protein conformational transformations. Based on this understanding, we want to develop new methods to maximize the information that can be obtained from protein crystals using X-ray crystallography, and to improve the cryopreservation of cells and tissues.
We have recently developed two methods that have significant potential to impact our understanding of protein structure and dynamics. The first allows us to cool crystals 100 times faster than in conventional flash cooling methods. Most crystals can now be successfully cooled without any penetrating cryoprotectants, and the resulting X-ray determined protein structures are closer to the biologically relevant room-temperature structure. The second method allows us to collect high quality data from many proteins as a continuous function of temperature between 300 K and 100 K, including in the heretofore inaccessible region between 220 K and 180 K, near the protein dynamical transition. This makes possible a variety of studies of the conformational energy landscape and protein-solvent interactions.
We are seeking a postdoctoral associate to continue and extend our current program, which includes a variety of physical measurements in addition to synchrotron-based X-ray crystallography. Candidates should have excellent "hands-on" experimental skills, interests in physics, physical chemistry and protein structure/function, and some synchrotron-based X-ray diffraction experience. They should be able to work quickly and efficiently, with a keen eye for what is important. Excellent oral and written communication skills in English are also a prerequisite. Because of the difficulty of interviewing foreign candidates, candidates with US or Canadian citizenship or visa status in the US are strongly preferred.
Please submit: CV and contact info of 3 references.
Person to contact: Robert Thorne
Email address: ret6@cornell.edu
Phone number: 607 255 6487
Univ of Wisconsin
A Postdoctoral Fellow position is available immediately to continue a successful collaborative study on the molecular mechanisms of action for the phytochrome family of photoreceptors. Phytochromes are a unique class of biliproteins that enable the detection of red and far-red light via photoconversion between two stable conformers, a ground state Pr form that absorbs red light, and a photoactivated Pfr state that absorbs far-red light. Phytochromes were first discovered in higher plants where they direct much of plant photomorphogenesis and have more recently been found throughout the microbial world. We have recently made great strides in understanding how phytochromes function at the atomic level, including the recent solution of the first structure of the photosensing region in the Pfr state. The postdoctoral fellow will be part of a larger team of scientists using a combination of x-ray crystallographic, solution NMR, and single-particle electron microscopic approaches to determine how rotation of the bilin chromophore during photoconversion is transduced into various signaling cascades. Ultimately, the project hopes to redesign phytochromes for agricultural benefit and as novel cellular photoswitches and fluorophores.
Recent publications derived from the project include:
Karniol et al. (2005) Biochem. J. 392: 103-116.
Wagner et al. (2005) Nature 438: 325-331.
Wagner et al. (2007) J. Biol. Chem. 282: 12298-12309.
Wagner et al. (2008) J. Biol. Chem. 283: 12212-12226.
Ulijasz et al. (2008) J. Biol. Chem. 283: 21251-21266.
Cornilescu et al. (2008) J. Mol. Biol. 383: 403-413.
Ulijasz et al. (2009) J. Biol. Chem. 284: 29757-29772.
Ulijasz et al. (2010) Nature 463: 250-254.
The University Wisconsin is a center of excellence in all aspects of biology with top-flight facilities for x-ray crystallographic and NMR-based structural approaches. The University is located in Madison, the capitol of Wisconsin. Madison is a diverse community, which boasts an exceptional living environment with numerous cultural, sport and recreational activities close by.
Requirements: Ph.D in structural biology or related areas. Experience with various molecular and atomic structure techniques and a broad background in protein chemistry would be very helpful. A competitive salary (commensurate with experience), fringe benefits including health insurance, and travel support to meetings are available. Funding is for at least 2 years with additional years possible depending on funding. The University of Wisconsin is an Equal Opportunity/Affirmative Action Employer.
Application Instructions: Send CV, copies of relevant publications, a cover letter detailing experience, and three letters of recommendations to: Dr. Richard D. Vierstra
Department of Genetics
425-G Henry Mall
University of Wisconsin
Madison WI 53706
or by email at vierstra@wisc.edu. Questions about this position can be addressed via emai or by phone (608-262-8215). Applications will be accepted until a suitable candidate is hired.
Post Doctoral Associate - Structural Biology-21308
Genzyme Corporation
Genzyme Corporation, ranked as one of the foremost biotechnology companies in the world, is committed to providing an exceptional environment in which individuals can excel, and achieve their professional and personal goals. Genzyme's people and culture have been consistently recognized for excellence. For example, we have been named several times to Fortune's list of the 100 Best Companies to Work For in the United States. We also consistently rank among the top employers for scientists in surveys of Science readers. Genzyme's local offices and facilities in Europe and other parts of the world have earned similar distinction as respected employers. By applying for a position with Genzyme, you are taking the first step toward becoming a part of our dynamic and talented team, and sharing in our continued success.
Job Responsibilities/Department Description:
We have a postdoctoral position open in the Fragment-Based Drug Discovery (FBDD) group in Drug and Biomaterial R&D at Genzyme Corporation in Waltham, MA. We are seeking a highly motivated recent PhD graduate in protein X-ray crystallography for a two-year position with a possible one-year extension. This position offers opportunities to work on structural biology of protein targets of therapeutic interest for FBDD approach, which involves activities from construct design to structural determination of target protein in complex with substrates or inhibitors. The successful candidate will have access to our cutting edge FBDD technology, including state of the art crystallization equipment and X-ray diffraction system.
Basic Qualifications:
PhD in structural biology or related disciplines (biochemistry, biophysics) with track record of solving X-ray crystal structures of proteins and protein complexes. Experience with construct design, protein purification, protein crystallization, data collection, structure determination and interpretation are essential.
Preferred Qualifications:
Strong background in biochemistry with in-depth understanding of ligand-protein interactions and familiarity with techniques such as ITC, surface plasmon resonance etc. to characterize proteins in support of structural biology is highly desired.
Please apply for the position online at www.Genzyme.com/careers job number 21308
Post-doctoral Position in Structural Enzymology
Univ of Wisconsin
A post-doctoral position will be available starting July 1, 2010 in the group of Dr. Nicholas R. Silvaggi at the University of Wisconsin-Milwaukee. Our lab uses X-ray crystallography, steady-state enzyme kinetics, and complimentary biochemical and biophysical techniques, to probe the structure and function of antibiotic biosynthetic enzymes. Antibiotic resistance is a serious and persistent problem that requires the continual development of new, effective antibiotics. The ultimate goal of our research is to apply lessons learned from natural product biosynthetic strategies to the enzymatic or chemoenzymatic synthesis of new antibiotics.
The laboratory is located in newly-renovated space in the Department of Chemistry and Biochemistry, which supports 23 enthusiastic faculty members and 75 graduate students and postdoctoral researchers. The department is connected to the Milwaukee Institute of Drug Discovery, whose focus includes the development of new therapies for microbial and parasitic diseases with emphasis on multi-drug resistant infections. More information about the department and laboratory can be found at: http://alchemy.chem.uwm.edu and http://alchemy.chem.uwm.edu/research/silvaggi. We have access to a state-of-the-art Rigaku home source and dedicated beamtime at the Advanced Photon Source (APS) through the LS-CAT.
The successful candidate will have received their doctoral degree in biochemistry or biophysics by July 2010, possess excellent written and oral communication skills, and perform well in a collaborative environment. Previous experience with recombinant DNA techniques, protein expression, and purification is required. Previous structural biology experience is an advantage, but is not necessary. To apply, please submit a cover letter including a brief description of research experience, scientific interests, and training goals, a C.V. with a list of publications, and contact information (e-mail address and phone number) for three references to: silvaggi@uwm.edu. Informal inquiries are welcome at the same address. Review of applications will begin immediately and continue until the position is filled.
Mineralogisch-Petrographisches Institut, Universität
Department: Institute of Mineralogy
Location: Hamburg, Germany
Start Date: Immediate
Duration: 2 years;
Description: Nanoscale structure and phase transitions in relaxor-ferroelectric mixed crystals. Multifrequency Raman spectroscopy on novel ferroelectric materials under an electric field. Analysis of preferred atomic clusters and their influence on relaxor macroproperties. Academic degree (PhD) required in one of the following: Solid State Physics, Mineralogy/Crystallography, and Solid State Chemistry. We are searching for strongly motivated and determined candidates with ability to work in a team and experience in the field of structural analysis of single crystals. Experimental skills in solid state spectroscopy and laser alignment are preferable.
Please submit: Application letter, full CV, copies of degree certificates, names and addresses of referees.
Person to contact: Prof. Boriana Mihailova
Surface mail address: Mineralogisch-Petrographisches Institut, Universität
Hamburg, Grindelallee 48, 20146 Hamburg
Email address: boriana.mihailova@uni-hamburg.de
Hauptman Woodward Medical Research Institute
Contact:
Tim Umland or Wayne Schultz
Email umland@hwi.buffalo.edu or schultz@hwi.buffalo.edu
Description:
The laboratories of Drs. L. Wayne Schultz and Tim Umland are seeking a highly motivated individual to participate in a joint interdisciplinary research project investigating Influenza A and SARS-CoV virus-host protein-protein interactions and structures. A position at the Post-Doctoral level is available, to be fill as soon as possible. Competitive applicants should have demonstrated scientific productivity and innovation at the graduate level, and possess a Ph.D., M.D., or similar degree. The successful applicant will have previous experience in all aspects of macromolecular crystallography, as well as molecular biology, protein expression and purification. They will interact with our groups to determine the crystal structures of virus-host protein complexes important in dictating host tropism. Salary and benefits are competitive, and funding is available for up to 2 years.
The Hauptman-Woodward Medical Research Institute (HWI) is a private, not-for-profit organization studying the structures and functions of macromolecules of biomedical interest. HWI houses the Department of Structural Biology of the State University of New York at Buffalo's School of Medicine and Biomedical Sciences. HWI is housed in a new building located on the Buffalo-Niagara Medical Campus, a consortium of research, clinical, and educational institutions founded to cultivate a world-class medical campus in state-of-the art facilities in downtown Buffalo, NY, USA.
To apply for a post-doctoral position, please send your CV and the names of three references to Drs. Schultz (schultz@hwi.buffalo.edu) and Umland (umland@hwi.buffalo.edu). Please visit the web site for the Laboratory for the Study of Infectious Diseases (LSID) for additional information: http://labs.hwi.buffalo.edu/lsid
The Hauptman-Woodward Institute is an Equal Opportunity Employer.
Research Investigator
Bristol-Myers Squibb
Department: Analytical Research and Development
Location: Wallingford, CT 06492 Start
Date: ASAP
Description: The successful candidate will work in a state of the art Solid State Chemistry laboratory for X-ray single crystal structure determination, powder X-ray diffraction and solid-state characterization of drug bulks. As a member of a highly effective team, they will provide crystallography/solid-state chemistry collaboration in support of drug discovery and preclinical compound optimization, as well as product development programs. The candidate major responsibilities will include: 1. Preparation of single crystals and structure determination of discovery lead compounds and intermediates; 2. Solid-state analysis of bulks in support of API crystallization efforts and pre-formulation characterization; 3. Routine maintenance of the lab hardware and update of the application software; 4. Independent planning and execution of R&D projects, effective oral communication, timely written documentation, and data base entry of results. The candidate will also have the opportunity to develop cross site interactions with process chemists and pharmaceutical scientists and participate in the final form selection, salt and polymorph screening of Active Pharmaceutical Ingredients, API. A PhD, MS (4 years of experience) or BS (7 years of experience) with background in chemistry or engineering is sought. The candidate should have hands-on experience with chemical crystallography, including X-ray diffraction data collection/processing/analysis and structure solution/refinement. Strong experience in crystallization of organic/inorganic materials and preparation of crystalline salts is also required. A working knowledge of physical characterization techniques (e.g. thermal analysis, microscopy, sorption analysis) for chemical/pharmaceutical bulk solids is a plus. Independence and creativity, strong organizational and written/verbal communication skills as well as a demonstrated ability to work within an interdisciplinary research team are essential.
Please submit: CV, coverletter, names of 3 references
Person to contact: Dr. Qi Gao
Email address: qi.gao@bms.com
Phone number: 732-227-6063
Job Posted: 10/28/09
Scientist/Senior Scientist - X-Ray Crystallographer in China
Crown Bioscience
Location: Beijing, China
URL: www.crownbio.com
Start Date: as soon as possible
Description: We are seeking highly motivated x-ray crystallographer and protein scientists in our Structural Biology Department at the level of senior Scientist or Scientist depending on qualifications. The successful candidate will be primarily responsible for protein crystallization and structure determination and refinement. The work includes optimization of existing strategies and crystallizing proteins in the presence or absence of small molecule ligands. Experience with protein crystallization, diffraction data collection (in house and synchrotron), structure determination and refinement is required. Experience with high throughput gene-to-structure work including gene cloning, gene expression in different systems (E. coli, baculovirus, and mammalian cells), protein purification are preferred. You are also responsible for writing standard operation procedures, reports and reviews, presenting seminars and interacting with clients regarding work performed, while preparing abstracts, posters, and manuscripts for scientific meetings and publication.
Please submit: CV
Person to contact: Max Wang
Email address: maxwang@crownbio.com
Phone number: +86-10-69719900 ext 501
Job Posted: 10/15/09
Senior Scientific Software Engineer
Rayonix
About the job
We are seeking a Senior Scientific Software Engineer for the design and development of software to support state-of-the-art scientific X-ray detectors. You will be the key contributor in new products and services, using your science background and scientific programming skills. You will be the core contributor in the design and development of software for a major new instrument family, working in close association with Dr. Michael Blum, founder and CEO of Rayonix. In addition, you will work with Dr. Blum and scientists world-wide whose novel research efforts require on-going development and innovation with existing products. You will also manage and mentor other IT-related staff.
About the company
Rayonix has an international reputation for providing the most advanced large area X-ray detectors. These instruments are utilized in nearly every major synchrotron across the globe, as well as numerous academic and industrial labs. Our detectors are being used to push forward the frontiers of scientific knowledge in a myriad of different applications, including macromolecular crystallography, small angle X-ray scattering (SAXS), polymers, surface science, and materials science. We have built our reputation on the excellent data quality, solid reliability, ease of use of our instruments, and extraordinary support for our researcher-customers.
While our work is quite complex, our work-life is very simple: We are casual, fun, flexible, hard working, and committed to being the very best at what we do.
Qualifications:
Candidates considered first for this job will have:
- At least three years of scientific programming using C and C++, Linux/Unix, and more recent applications of object-oriented languages (Python, Perl, etc.)
- Broad product development capability: code architecture, project design, programming, documentation and QA
- Experience with GUI development tools
- Experience with instrument and machine control issues, database structures, and client server applications; experience with scientific instrumentation is preferred
- Excellent written and oral communications
- An advanced degree in physics, engineering, biology, or crystallography would be advantageous
- Experience with scientific instrumentation is desirable; experience with X-ray detectors or other CCD (charge-coupled device) applications even better.
Rayonix is most decidedly an equal opportunity employer and qualified candidates with diverse backgrounds are strongly encouraged to apply.
To apply, please go to: http://tinyurl.com/Rayonix-Jobs.
Rigaku Automation, Inc.
Summary
Rigaku Automation, Inc., a subsidiary of Rigaku Americas Corporation, located in Carlsbad, CA, is a world leader in robotic automation in the structural biology market. We are looking for a unique experienced business and marketing professional who possesses strong scientific and communication skills. The ideal candidate will have the ability to plan, direct, and coordinate the definition, development, and launch of the CrystalMation product line and services by performing the following duties or by leveraging cross-functional resources. Must be an experienced public speaker with good customer rapport. Requires 40% domestic/international travel.
Essential Duties and Responsibilities
· Creates business plans for assigned product(s) or product line(s) that establish marketing goals to ensure share of market and profitability of products and/or services.
· Develops and executes marketing plans and programs, including channel and partner relationship recommendations (both short and long range), to ensure the profit, growth and expansion of company products and/or services.
· Researches, analyzes, and monitors financial and technological factors to capitalize market opportunities and minimize the effects of competitor activity.
· Works closely with Sales, Corporate Marketing, and Customer Support to competitively differentiate and position products and resolve issues/problems that affect product success.
· Gathers data from market and customers to create marketing requirements and specifications. Supports the broad efforts of the product management group to assist in achieving corporate objectives.
· Coordinates product release schedule with development to ensure that releases achieve marketing objectives in addition to technical objectives.
Education and/or Eeperience
Bachelor's degree and 5+ years experience at a director level, or equivalent combination of education and experience. Master's or Ph.D. in life sciences a+.
We offer competitive salaries and benefits. For immediate consideration, please email your resume with salary requirements to raiJobs@Rigaku.com or visit www.rigaku.com.
Other Positions
Macromolecular X-ray Crystallographer
Xtal BioStructures, Inc.
Ph.D. Protein Crystallographer: We seek an experienced crystallographer with post-doctoral experience to participate in a number of our diverse structural biology activities. These activities include: 1) structure-based drug design efforts; 2) structural analysis of protein therapeutic candidates; and 3) crystal structure analysis of proteins playing key roles in human disease. Candidates should have a wide range of active skills: protein crystallization and optimization, structure determination by molecular replacement, MIR and/or MAD methods, with experience in a variety of computational programs, experience with home and synchrotron data collection, and the ability to interpret and communicate structural information. Experience/facility with any or all of the following is a plus: protein construct design; cloning, expression and purification of proteins; molecular modeling; biophysical characterization (CD, ITC, SPR). The successful candidate will fit well in a collaborative environment and must exhibit strong leadership and excellent communication skills.
Please submit: CV and names of references
Person to contact: Robert Suto
Email address: robert@xtalbiostructures.com
HHMI Interdisciplinary Science Fellow
Vassar College
Vassar College seeks applications for an HHMI Interdisciplinary Science Fellow position beginning Fall 2010.
Vassar College is an equal opportunity/affirmative action employer and is strongly and actively committed to diversity within its community. Applications from members of historically underrepresented groups are especially encouraged.
We seek candidates with strong interdisciplinary research skills who are interested in gaining experience teaching in a liberal arts environment. The one-year Fellowship (with possible extension to a second year) includes a teaching load of 2-3 courses per year at the intermediate or advanced level and the opportunity for various research collaborations. The Fellow will serve as a resource for science faculty and students interested in computational or integrative research projects; be involved in student projects and collaborate with faculty; and help drive faculty development in cutting edge, interdisciplinary research. We offer a competitive salary, an ample supplies budget, and laboratory space, as well as access to a parallel computing cluster dedicated to the analysis of large datasets.
Applicants with a PhD in a scientific field who are at any stage of their career are invited to apply. Background in computational methods applied to the sciences is highly desirable. Applicants who are early in their careers can be paired with a senior faculty member to serve as a professional mentor.
Located in the scenic Mid-Hudson Valley, Vassar College is a highly selective, residential, co-educational liberal arts college. Vassar is strongly committed to fostering a community that reflects the values of a liberal arts education and to promoting an environment of equality, inclusion and respect for difference. Vassar College is an affirmative action, equal opportunity employer, and applications from members of historically under-represented groups are especially encouraged.
Applicants should submit a cover letter, curriculum vitae, representative reprints, a statement of research interests and goals, a statement of teaching interests and philosophy, and three letters of reference. To apply please visit https://employment.vassar.edu/. Review of applications is ongoing and will continue until the position is filled.
