Postdoctoral Research Associate - Purdue University

Department: Biological Sciences
Location: West Lafayette, IN, USA
Start Date: Immediate
Duration: 1 year; extension possible
Description: Postdoctoral Position in Structural Biology of Membrane Proteins. A postdoctoral is sought to work on structure-function of one or more integral membrane proteins or protein complexes in a multi-investigator multi-institutional project centered in the structural biology group of the Dept. of Biological Sciences, Purdue University. The major expertise(s) that the person should bring to the projects include x-ray crystallography and/or structure analysis by single particle cryo-electron microscopy. Experience in membrane protein purification is relevant. The five laboratories at Purdue involved in this project will move to a new building at the end of this year. Interested parties should respond, including a CV and the names/addresses of 3 references, to W. A. Cramer (waclab@purdue.edu) by November 23, 2009.

Please submit: CV; 3 letters of reference
Person to contact: W. A. Cramer
Surface mail address: 915 West State St., Lilly Hall, W. Lafayette, IN 47907
Email address: waclab@purdue.edu
Phone number: 765-494-4956
Fax number: 765-496-1189
Job Posted: 11/03/09

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Postdoctoral Research Associate - Cold Spring Laboratory

  Applications are invited for postdoctoral positions at Cold Spring Harbor Laboratory (CSHL) from highly enthusiastic individuals with strong interest in utilizing structural, electrophysiological, and biochemical approaches to study fundamental problems in ion and substrate transports across the membrane. Our goal is to understand molecular basis for synaptic transmission and neurological disorders and diseases. We use x-ray crystallography to obtain atomic structures of target membrane/glyco proteins and test structure-based functional hypotheses by various techniques including electrophysiology, analytical centrifugation, and fluorescence assay. We are equipped with a state-of-the-art facility to conduct membrane/glyco protein crystallography and functional studies including a high-throughput protein screening system, an automated crystallization screening device, a recently updated home x-ray source, electrophysiology rigs, and other setups such as isothermal titration colorimetry device. CSHL is also located within 30 min driving distance from the National Synchrotron Light Source at Brookhaven National Laboratory. Most importantly, a highly collaborative environment at CSHL provides a unique opportunity for postdocs to interact with scientists from various fields including cancer biology, neuroscience, and plant biology. Candidates must hold (or soon expect to hold) PhD in biochemistry, molecular biology, biophysics or related fields. Strong background in molecular biology, biochemistry, large-scale protein expression in eukaryotic and prokaryotic cells, and purification of membrane/glyco proteins is desired. Experience in x-ray crystallography or electrophysiology is desirable but not necessary. For more information, please check the laboratory website (http://www.cshl.edu/public/SCIENCE/furukawa.html) and contact me via email. Please send CV, a summary of research experience and interest, and three references to Hiro Furukawa by email at furukawa@cshl.edu

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Postdoctoral Positions - Vanderbilt University

 Two postdoctoral positions funded by US NIH grants are available immediately to work on structural studies of native and chemically modified nucleic acids, protein-nucleic acid interactions or the KaiABC cyanobacterial circadian clock. An overview of current projects in our laboratory can be found at: http://structbio.vanderbilt.edu/~eglim/

For recent publications in the areas of DNA, RNA and protein-nucleic acid interactions, please see: J. Am. Chem. Soc. 2009, 131, p12548; J. Biol. Chem. 2009, 284, p22467; Chem. Comm., 2009, p2017; RNA 2008, 14, p2125; Cell Cycle 2008, 7, p2562; J. Biol. Chem. 2007, 282, p36421; Nucleic Acids Res. 2007, 35, p6424; Annu. Rev. Biophys. Biomol. Struct. 2007, 36, p281; Acc. Chem. Res. 2007, 40, p197; J. Am. Chem. Soc. 2006, 128, p10847. For recent publications focusing on the structure/function of the KaiABC clock, please see: Science 2008, 322, p697; EMBO J. 2008, 27, p1767; PLoS Biol. 2007, 5, e93; EMBO J. 2006, 25, p2017; Proc. Natl. Acad. Sci. USA 2004, 101, p13933; Nature Struct. Molec. Biol. 2004, 11, p584; Mol. Cell 2004, 15, p375.

All crystallographic data collections are being conducted at the Advanced Photon Source, Argonne National Laboratory, to which we have extensive access via the Life Sciences CAT at sector 21. Candidates must have a recent Ph.D. and a strong background in chemistry or biochemistry as well as a basic knowledge of X-ray crystallography.

Please e-mail your curriculum vitae and the names of three references to: Prof. Martin Egli, Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA. E-MAIL: martin.egli@vanderbilt.edu

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Research Fellow Opportunity - Kelly Scientific 

  Kelly Scientific has an immediate direct hire opportunity for a research fellow to join a laboratory in Ann Arbor, MI. The research projects involve the study of proteins using x-ray crystallography as well as biochemical, biophysics, and chemical genomics techniques. The research is focused on a number of synaptic adhesion molecules known to play a role in several neuro-psychiatric disorders and on a transcription factor that mediates neuro-adaptive and behavioral changes following chronic drug abuse.

Experience techniques needed include, but not limited to: macromolecular crystallization, purifying proteins, protein gel electrophoresis, expressing recombinant proteins, DNA gel electrophoresis, standard cloning techniques, and growing bacterial cultures and insect cell cultures.

Qualifications include a PhD in life sciences earned within the past 3 years. Relevant experience in the study of macromolecular crystallography is highly desirable. Good written and oral communication skills are essential. Interested candidates should e-mail their CV and 3 references to Mamie_Denton@kellyscientific.com.

Mamie Denton
Senior Scientific Recruiter

Kelly Scientific Resources

248-848-9360

248-848-9315 (fax)
www.kellyscientific.com

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Postdoctoral Fellow - Cold Spring Harbor Laboratory

Location: New York
Description: Applications are invited for postdoctoral positions at Cold Spring Harbor Laboratory (CSHL) from highly enthusiastic individuals with strong interest in utilizing structural, electrophysiological, and biochemical approaches to study fundamental problems in ion and substrate transports across the membrane. Our goal is to understand molecular basis for synaptic transmission and neurological disorders and diseases. We use x-ray crystallography to obtain atomic structures of target membrane/glyco proteins and test structure-based functional hypotheses by various techniques including electrophysiology, analytical centrifugation, and fluorescence assay. We are equipped with a state-of-the-art facility to conduct membrane/glyco protein crystallography and functional studies including a high-throughput protein screening system, an automated crystallization screening device, a recently updated home x-ray source, electrophysiology rigs, and other setups such as isothermal titration colorimetry device. CSHL is also located within 30 min driving distance from the National Synchrotron Light Source at Brookhaven National Laboratory. Most importantly, a highly collaborative environment at CSHL provides a unique opportunity for postdocs to interact with scientists from various fields including cancer biology, neuroscience, and plant biology. Candidates must hold (or soon expect to hold) PhD in biochemistry, molecular biology, biophysics or related fields. Strong background in molecular biology, biochemistry, large-scale protein expression in eukaryotic and prokaryotic cells, and purification of membrane/glyco proteins is desired. Experience in x-ray crystallography or electrophysiology is desirable but not necessary. For more information, please check the laboratory website (http://www.cshl.edu/public/SCIENCE/furukawa.html) or contact me via email. Please send CV, a summary of research experience and interest, and three references to Hiro Furukawa by email at furukawa@cshl.edu

Please submit: CV, Brief description of research interest, 3 references
Person to contact: Hiro Furukawa
Surface mail address: 1 Bungtown Rd., Cold Spring Harbor, NY 11724
Email address: furukawa@cshl.edu
Phone number: 516-367-8872
Fax number: 516-367-8873
Job Posted: 10/27/09 

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Postdoctoral Associate - Cornell University

Department: MacCHESS
Location: Ithaca, NY
URL: search-lepp@cornell.edu
Description: Post-doctoral Associate - Biological Small-Angle Solution Scattering Cornell High-Energy Synchrotron Source The Macromolecular Diffraction Facility of the Cornell High-Energy Synchrotron Source (MacCHESS) has an opening for a post-doctoral associate. Applicants should have a Ph.D. degree in a field relevant to structural biology. Preference will be given to those with experience in x-ray solution scattering on biological systems (SAXS and WAXS). The successful candidate will be expected to collaborate with visiting research groups collecting data at MacCHESS. Activities will include applying state-of-the art algorithms to BioSAXS data, modeling macromolecular complexes, or studying conformationally- variable regions of proteins. Experience in developing hardware and software for automation including microfluidics is also desirable. Located on an ivy-league university campus in picturesque upstate New York, the Cornell High-Energy Synchrotron Source (CHESS) serves a world-wide user base of structural biologists, chemists, physicists, and engineers. MacCHESS is an NIH-supported National Resource providing support for structural biology at CHESS. MacCHESS is a heavily team-oriented environment. Good clear communication skills are a must, including fluency in the English language. This position is a 1-year appointment, renewable for up to 3 years total, contingent upon availability of funds and employee performance. Please provide an application and arrange to have at least three letters of reference sent to: Dr. Marian Szebenyi, Chair Postdoctoral Associate Search Committee Newman Lab Cornell University Ithaca, NY 14853 USA Applications should include a cover letter, curriculum vita, a publication list, and a detailed summary of research experience and interests. Electronic submissions and inquiries may be addressed to search-lepp@cornell.edu. Deadline for application is November 15, 2009. Starting date is negotiable. Cornell is an equal opportunity employer.

Phone number: 607-255-4952
Fax number: 607-254-4552
Job Posted: 10/19/09

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NIH Funded Post-Doctoral Fellow in RNA Structure & Function - The University of Rochester Medical Center
Department: Department of Biochemistry & Biophysics
Location: Rochester, New York
URL: dbb.urmc.rochester.edu/labs/wedekind/Site/Wedekind_Home.html
Start Date: immediately
Duration: 1-2 year or more
Description: The University of Rochester Medical Center Department of Biochemistry & Biophysics Rochester, New York, USA An NIH funded post-doctoral position is available immediately to investigate the mechanisms of action of riboswitches and ribozymes. Primary experimental methods include X-ray crystallography, computation refinement, single-turnover kinetics, small angle X-ray scattering (SAXS), synthetic organic chemistry, protein purification, dynamic light scattering, and molecular biology. Qualified candidates must hold a Ph.D. in chemistry, biochemistry or a related field. Prior experience with X-ray crystallography is preferred. Post-doctoral fellows will have an opportunity to work with other trainees and staff members in a modern research lab with excellent equipment and resources. Travel opportunities are also available for data collection and to present scientific findings at meetings. For additional information please send a curriculum vitae and the names of three references to Prof. Joseph Wedekind (joseph.wedekind@rochester.edu).

Please submit: cv, names of three references
Person to contact: Joseph Wedekind
Surface mail address: 601 Elmwood Avenue, Box 712, Dept. Biochemistry & Biophysics
Email address: joseph.wedekind@rochester.edu
Phone number: (585) 273-4516
Fax number: (585) 275-6007
Job Posted: 10/15/09 

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Post-Doctoral Fellow - St. Jude Children's Research Hospital
Department: Structural Biology
Location: Memphis, TN
Start Date: immediately
Description: A post-doctoral position in Structural Biology at St. Jude Children's Research Hospital is available for highly motivated applicants to study the structure and function of replication proteins and their interaction with DNA. This position is available for applicants with a strong interest in protein crystallography and structural biology. Applicants should have recent PhD experience in biochemistry, molecular biology, crystallography, or a related field. The Structural Biology Department at St. Jude is highly interactive and has state-of-the-art facilities for structural studies, including shared synchrotron time. To apply, please send a cover letter, CV with list of publications, and 3 references.

Please submit: cover letter, CV with list of publications, and 3 references
Person to contact: Eric Enemark
Surface mail address: Department of Structural Biology, St. Jude Children's Research Hospital, Mail Stop 311, 262 Danny Thomas Place, Memphis, TN 38105
Email address: Eric.Enemark@stjude.org
Job Posted: 09/28/09 

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Postdoc Position in Structural Biology & Biochemistry - University of California San Diego

Department: School of Pharmacy
Location: La Jolla
Start Date: Jan 2010
Description: Postdoc Job Description: A full-time postdoctoral position is available at UC San Diego. We are looking for a highly motivated postdoctoral research fellow to join our laboratory. We are interested in structure-function studies of protein complexes involved in DNA repair process using a combination of x-ray crystallography, biochemical, and biophysical techniques. Qualifications: Successful candidates should have received a Ph.D. degree in structural biology, biophysics, biochemistry, chemistry, or related discipline. Applicants with experience in cloning and expression of recombinant protein in bacterial, yeast or insect cell systems, large-scale protein purification, macromolecular crystallization and structure determination are preferred. Applicants with a strong background in protein and nucleic acids biochemistry are also encouraged to apply. Good written and oral communication skills are essential. Procedure to Apply: Please send your CV, including contact information of 3 references (address, phone, and email) and list of your experimental expertise to Dong Wang, PhD. dongwang@stanford.edu.

Please submit: CV, including contact information of 3 references (address, phone, and email) and list of your experimental expertise
Person to contact: Dong Wang, PhD.
Email address: dongwang@stanford.edu
Job Posted: 09/23/09 

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Research Associate - Stanford Synchrotron Radiation Lightsource
Location: SLAC National Accelerator Lab
URL: www-ssrl.slac.stanford.edu/
Start Date: ASAP
Description: The Stanford Synchrotron Radiation Lightsource (SSRL) has an opening for a Research Associate to help support our materials sciences small angle X-ray scattering program. This position has a component (roughly 50%) that involves beam line development at SSRL and a part (remaining 50%) involving SAXS related materials science. The facility part will involve instrument development at the SSRL materials sciences SAXS beam line (1-4). This will involve rebuilding much of the in-hutch beam line components (e.g., slits, flight paths, sample stages, etc.). There will also be some development of sample environments such as furnaces and an in-vacuum, grazing incidence capability. The science part of this position is somewhat flexible but will involve studies of complex materials using SAXS and related techniques (e.g., diffraction). It is likely that some of this will include collaborative studies with investigators at universities and national labs. Qualifications: a Ph.D. in a physical science. Experience with synchrotron small angle X-ray and/or neutron scattering. Good interpersonal skills. Some experience with instrumentation design and development and computer-instrument interfacing is desirable.

Please submit: CV
Person to contact: Mike Toney
Email address: mftoney@slac.stanford.edu

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Postdoctoral Fellow - University of Minnesota
Department: Biochemistry, Molecular Biology, and Biophysics
Location: Minneapolis, MN
URL: www.cbs.umn.edu/BMBB/faculty/Aihara.H.shtml
Start Date: January, 2010
Duration: 2 years
Description: A postdoctoral position will be open in January 2010 to conduct crystallographic studies of protein-DNA complexes. Our laboratory studies structure and function of various DNA-processing enzymes primarily using x-ray crystallography. Current research projects include retroviral integrases, tyrosine family of site-specific recombinases, and Holliday-junction resolvases. Successful candidate should have research experience (and Ph.D.) in biochemistry, biophysics, or similar disciplines. Prior experience with x-ray crystallography or other structural biology techniques is preferred. The University of Minnesota at Twin Cities offers superb research environment with state of the art x-ray diffraction and robotic crystallization facilities.

Please submit: CV & contact info of 3 references
Person to contact: Hideki Aihara
Surface mail address: 6-155 Jackson Hall, 321 Church Street S.E. Minneapolis, MN 55455
Email address: aihar001@umn.edu
Phone number: 612-624-1491
Job Posted: 09/17/09 

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Postdoctoral Researcher: Protein Crystallography and Electron Cryo-Microscopy - University of Kansas
Department: Department of Molecular Biosciences
Location: 1200 Sunnyside Ave., Lawrence, KS 66045
Start Date: Immediately
Duration: Up to 2 years, extensible
Description: An NIH-funded postdoctoral position is immediately available for a highly motivated individual with a strong interest in structure and function of macromolecular complexes in the laboratory of Dr. Liang Tang at the Department of Molecular Biosciences, University of Kansas (http://www.molecularbiosciences.ku.edu/faculty/tang.html). The projects include structural studies on protein complexes in the Type III secretion system and signal transduction in pathogenic bacteria by means of X-ray crystallography and electron cryo-microscopy. Multiple protein crystals are available and need to be optimized. The laboratory has easy access to a Rigaku RU-H3RHB X-ray generator with an R-axis IV++ imaging plate system and a 200kV FEI transmission electron microscope equipped with field emission gun both located in campus, and has regular access to synchrotron radiation beamlines. The position is funded up to two years, and may be extended dependent on performance and availability of funding. This position requires a Ph.D. in biochemistry or a related field, with a strong background in protein crystallography. For more information and to apply, go to: https://jobs.ku.edu and search with the job number 00004831. Review of applications has begun and will continue until the position is filled. EO/AA Employer.

Please submit: CV, 3 references, cover letter
Person to contact: Dr. Liang Tang
Surface mail address: Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Ave., Lawrence, KS 66045
Email address: tangl@ku.edu
Phone number: 785-864-5838
Fax number: 785-864-5294
Job Posted: 09/08/09 

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Postdoctoral Position in Protein Crystallography

Baylor College of Medicine

A Postdoctoral position is available immediately to determine the three-dimensional crystal structure of protein complexes. A recent Ph.D. (0-2 years) in biochemistry, chemistry, or a closely related field is required. The ideal applicant must be highly self-motivated with excellent communication skills, and must have demonstrated experience (i.e. relevant publications) with macromolecular X-ray crystallography using MIR/MAD. Experience with gene cloning, site-directed mutagenesis, protein purification and crystallization is desirable. Salary will be commensurate with experience and is in addition to a generous fringe benefit package.

To apply, please send your current CV including a brief description of research interests and accomplishments, and the names and addresses of three referees to:

Dr. Francis Tsai, Associate Professor

Dept. of Biochemistry and Molecular Biology, and Molecular and Cellular Biology

Baylor College of Medicine

One Baylor Plaza MS:BCM125

Houston, TX 77030

e-mail: ftsai@bcm.tmc.edu

Baylor College of Medicine is an Equal Opportunity Employer.

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Postdoctoral Position in Solid State Organic Chemistry  - State University of Kansas

A postdoctoral position in solid state organic chemistry is available immediately for studies of ferroelastic and ferroelectric domain switching, crystal growth, crystallography, organic synthesis and molecular recognition phenomena in organic inclusion compounds and related materials. This position requires a strong background in solid-state organic chemistry; the project will focus on the design, synthesis and characterization of new organic ferroelastic and ferroelectric materials. The ideal applicant would have extensive experience in the area of crystallography, materials chemistry and organic synthesis. Duration of each position would be for one year with the possibility of extension to two years. Salary will be commensurate with experience and background. Along with a cover letter, send a CV and the names and addresses of three references to:

Prof. Mark D. Hollingsworth

Chemistry Dept, 213 CBC Building

Kansas State University

Manhattan, KS 66506-0401;

ph.: 785-532-2727

fax: 785-532-6666

e-mail: mdholl@ksu.edu

Review of applications will commence Feb. 1, 2010, but the search will be extended until a suitable applicant is of Regents policy, a background check is required. Kansas State University is an Equal Opportunity Employer, and it actively seeks diversity among its employees. 

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Postdoctoral Research Associate - Naval Research Laboratory

Department: Center for Biomolecular Science and Engineering
Location: Washington, DC, USA
Start Date: Immediate
Duration: 2 years; extension possible
Description: The crystallography group in the Center for Biomolecular Science and Engineering (CBMSE) is currently seeking a candidate for a Postdoctoral Fellowship to work on structural studies of single-domain antibodies. The major expertise(s) that the person should bring to the projects include x-ray crystallography and crystallization of macro-molecules. The successful candidate must have a demonstrated ability to independently conduct structural studies on macro-molecules. U.S. citizenship or permanent resident status is required at time of application. The stipend level is $69,764 annually. Travel and relocation expenses are paid, with limited funds available for professional travel if approved by the Laboratory. Interested parties should respond, including a CV and the names/addresses of 3 references, to J. R. Deschamps (deschamps@nrl.navy.mil).

Please submit: CV; 3 letters of reference
Person to contact: J. R. Deschamps
Surface mail address: 915 West State St., Lilly Hall, W. Lafayette, IN 47907
Email address: deschamps@nrl.navy.mil
Phone number: 202-767-0656

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Postdoctoral Associate - Cornell University

Department: Physics Department
Location: Ithaca, NY USA
Start date: Immediate through June 2010
Duration: 1+1 years; extension possible. 

Description:

Our group studies the physics of cryopreservation of protein solutions, protein crystals and other biological materials, and implications for the determination of protein structures by X-ray crystallography.  We want to understand what happens to water and protein when they are cooled in solution, inside crystals and inside cells; and how factors including cryoprotectants and cooling rates affect ice nucleation and growth and protein conformational transformations. Based on this understanding, we want to develop new methods to maximize the information that can be obtained from protein crystals using X-ray crystallography, and to improve the cryopreservation of cells and tissues.

We have recently developed two methods that have significant potential to impact our understanding of protein structure and dynamics.  The first allows us to cool crystals 100 times faster than in conventional flash cooling methods.  Most crystals can now be successfully cooled without any penetrating cryoprotectants, and the resulting X-ray determined protein structures are closer to the biologically relevant room-temperature structure.  The second method allows us to collect high quality data from many proteins as a continuous function of temperature between 300 K and 100 K, including in the heretofore inaccessible region between 220 K and 180 K, near the protein dynamical transition. This makes possible a variety of studies of the conformational energy landscape and protein-solvent interactions. 

We are seeking a postdoctoral associate to continue and extend our current program, which includes a variety of physical measurements in addition to synchrotron-based X-ray crystallography. Candidates should have excellent "hands-on" experimental skills, interests in physics, physical chemistry and protein structure/function, and some synchrotron-based X-ray diffraction experience. They should be able to work quickly and efficiently, with a keen eye for what is important. Excellent oral and written communication skills in English are also a prerequisite.   Because of the difficulty of interviewing foreign candidates, candidates with US or Canadian citizenship or visa status in the US are strongly preferred. 

Please submit: CV and contact info of 3 references.
Person to contact: Robert Thorne
Email address: ret6@cornell.edu
Phone number: 607 255 6487

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Postdoctoral Research Fellow - University of Wisconsin

  A Postdoctoral Fellow position is available immediately to continue a successful collaborative study on the molecular mechanisms of action for the phytochrome family of photoreceptors. Phytochromes are a unique class of biliproteins that enable the detection of red and far-red light via photoconversion between two stable conformers, a ground state Pr form that absorbs red light, and a photoactivated Pfr state that absorbs far-red light. Phytochromes were first discovered in higher plants where they direct much of plant photomorphogenesis and have more recently been found throughout the microbial world. We have recently made great strides in understanding how phytochromes function at the atomic level, including the recent solution of the first structure of the photosensing region in the Pfr state. The postdoctoral fellow will be part of a larger team of scientists using a combination of x-ray crystallographic, solution NMR, and single-particle electron microscopic approaches to determine how rotation of the bilin chromophore during photoconversion is transduced into various signaling cascades. Ultimately, the project hopes to redesign phytochromes for agricultural benefit and as novel cellular photoswitches and fluorophores.

Recent publications derived from the project include:

Karniol et al. (2005) Biochem. J. 392: 103-116.

Wagner et al. (2005) Nature 438: 325-331.

Wagner et al. (2007) J. Biol. Chem. 282: 12298-12309.
Wagner et al. (2008) J. Biol. Chem. 283: 12212-12226.
Ulijasz et al. (2008) J. Biol. Chem. 283: 21251-21266.
Cornilescu et al. (2008) J. Mol. Biol. 383: 403-413.
Ulijasz et al. (2009) J. Biol. Chem. 284: 29757-29772.
Ulijasz et al. (2010) Nature 463: 250-254.

The University Wisconsin is a center of excellence in all aspects of biology with top-flight facilities for x-ray crystallographic and NMR-based structural approaches. The University is located in Madison, the capitol of Wisconsin. Madison is a diverse community, which boasts an exceptional living environment with numerous cultural, sport and recreational activities close by.

Requirements: Ph.D in structural biology or related areas. Experience with various molecular and atomic structure techniques and a broad background in protein chemistry would be very helpful. A competitive salary (commensurate with experience), fringe benefits including health insurance, and travel support to meetings are available. Funding is for at least 2 years with additional years possible depending on funding. The University of Wisconsin is an Equal Opportunity/Affirmative Action Employer.

Application Instructions: Send CV, copies of relevant publications, a cover letter detailing experience, and three letters of recommendations to: Dr. Richard D. Vierstra

Department of Genetics

425-G Henry Mall

University of Wisconsin

Madison WI 53706

or by email at vierstra@wisc.edu. Questions about this position can be addressed via emai or by phone (608-262-8215).  Applications will be accepted until a suitable candidate is hired.

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Post Doctoral Associate - Structural Biology-21308

Genzyme Corporation

Genzyme Corporation, ranked as one of the foremost biotechnology companies in the world, is committed to providing an exceptional environment in which individuals can excel, and achieve their professional and personal goals. Genzyme's people and culture have been consistently recognized for excellence. For example, we have been named several times to Fortune's list of the 100 Best Companies to Work For in the United States. We also consistently rank among the top employers for scientists in surveys of Science readers. Genzyme's local offices and facilities in Europe and other parts of the world have earned similar distinction as respected employers. By applying for a position with Genzyme, you are taking the first step toward becoming a part of our dynamic and talented team, and sharing in our continued success.

Job Responsibilities/Department Description:
We have a postdoctoral position open in the Fragment-Based Drug Discovery (FBDD) group in Drug and Biomaterial R&D at Genzyme Corporation in Waltham, MA. We are seeking a highly motivated recent PhD graduate in protein X-ray crystallography for a two-year position with a possible one-year extension. This position offers opportunities to work on structural biology of protein targets of therapeutic interest for FBDD approach, which involves activities from construct design to structural determination of target protein in complex with substrates or inhibitors. The successful candidate will have access to our cutting edge FBDD technology, including state of the art crystallization equipment and X-ray diffraction system.

Basic Qualifications:
PhD in structural biology or related disciplines (biochemistry, biophysics) with track record of solving X-ray crystal structures of proteins and protein complexes. Experience with construct design, protein purification, protein crystallization, data collection, structure determination and interpretation are essential.

Preferred Qualifications:
Strong background in biochemistry with in-depth understanding of ligand-protein interactions and familiarity with techniques such as ITC, surface plasmon resonance etc. to characterize proteins in support of structural biology is highly desired.

Please apply for the position online at www.Genzyme.com/careers job number 21308

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Postdoctoral Associate - Mineralogisch-Petrographisches Institut, Universität

Department: Institute of Mineralogy
Location: Hamburg, Germany
Start Date: Immediate
Duration: 2 years;
Description: Nanoscale structure and phase transitions in relaxor-ferroelectric mixed crystals. Multifrequency Raman spectroscopy on novel ferroelectric materials under an electric field. Analysis of preferred atomic clusters and their influence on relaxor macroproperties. Academic degree (PhD) required in one of the following: Solid State Physics, Mineralogy/Crystallography, and Solid State Chemistry. We are searching for strongly motivated and determined candidates with ability to work in a team and experience in the field of structural analysis of single crystals. Experimental skills in solid state spectroscopy and laser alignment are preferable.

Please submit: Application letter, full CV, copies of degree certificates, names and addresses of referees.
Person to contact: Prof. Boriana Mihailova
Surface mail address: Mineralogisch-Petrographisches Institut, Universität
Hamburg, Grindelallee 48, 20146 Hamburg
Email address: boriana.mihailova@uni-hamburg.de

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Postdoctoral Researcher - Indiana University Molecular Structure Center

The Indiana University Molecular Structure Center (IUMSC) at Indiana University, Bloomington, Indiana, USA has an opening for a post-doctoral researcher. The successful candidate is expected to contribute to the operation of the X-ray crystallography laboratory and provide support to facility users. The candidate will be encouraged to develop her/his own independent scientific research while contributing to the lab's ongoing projects. The candidate should hold a Ph.D. in chemistry, physics, or a related field with a strong background in small molecule crystallography and materials characterization. Computing skills, including programming are a plus. The salary range for the position will be dependent on qualifications.

The IUMSC provides state-of-the-art service and research crystallography, including routine and non-routine small-molecule single-crystal X-ray structure determination and X-ray powder diffraction analysis to Indiana University. The laboratory has a full range of single crystal and powder X-ray diffractometers and accessory equipment. It is also involved in a wide range of advanced information technology projects to support crystallography. Additional information on the IUMSC can be found at http://www.iumsc.indiana.edu.  The post-doctoral position is for a one-year period; the desired start time is mid-May. For full consideration, the candidate should provide a detailed CV and publication list and arrange for two letters of recommendation to be sent to the address below by May 2, 2010.  Indiana University is an equal opportunity/affirmative action employer.

Contact:
Dr. Maren Pink,
Re: Postdoctoral position,
IUMSC, Chemistry Department,
800 E. Kirkwood Avenue,
Bloomington, IN 47405-7102, USA

e-mail: mpink@indiana.edu

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Postdoctorial Fellow - University Erlangen

At the synchrotron source PETRAIII, Hamburg, Germany a dedicated beamline to measure data for the pair distribution function will be built.  This beamline shall operate as a high energy powder diffractometer and will access a very large Q-range and enable fast data collection strategies.  Start date is July 1, 2010.

Contact: 

Prof. Dr. ReinhardNeder 

reinhard.neder@krist.uni-erlangen.de 

Further details at www.lks.physik.uni-erlangen/staff/users/neder. 

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Postdoctoral Fellowship - NIH Main Campus 

Postdoctoral positions are available in the Cell Biology and Biophysics Unit headed by Dr. Antonina Roll-Mecak at the National Institute of Neurological Disorders and Stroke.

The Roll-Mecak lab is interested in understanding the interplay between microtubules and their regulators and how tubulin post-translational modifications tune the behavior of motors and microtubule associated proteins (see for instance Roll-Mecak, A. and Vale, R.D. 2008. Nature, 451(7176):363-7; Roll-Mecak, A. and McNally, F.J. 2010. Curr. Opin. Cell Biol., 22(1):96-103). We use a combination of biochemistry, structural biology, cell biology and single-molecule fluorescence techniques. Thus, a postdoctoral fellow in the lab would have the opportunity to move between these techniques and build upon an already strong background in structural biology. Our lab is located in the Porter Center for Neuroscience on the NIH main campus in Bethesda. The NIH has a long tradition of research excellence in cytoskeletal biology and offers a stimulating environment for postdoctoral fellows interested in interdisciplinary training in biophysics and cell biology. The research facilities at NIH are outstanding and the lab has access to state-of-the-art equipment such as crystallization robots, liquid handling systems, TIRF and confocal microscopes. For more information, please visit: http://intra.ninds.nih.gov/rm_lab/

The position will be fully funded by the NIH. We are looking for candidates who wish to work on structural biology problems related to microtubule cytoskeleton dynamics regulation and have a strong background in X-ray crystallography, protein overexpression and purification.

Other details: Candidates should preferably have less than 3 years of postdoctoral experience and a strong publication record. Please send a CV, a one-page research experience summary, and contact information of three references to Antonina@mail.nih.gov Please write "Postdoctoral application" in the subject header.

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Postdoctoral Position - La Jolla Institute for Allergy & Immunology 

  We are looking for a qualified and highly motivated biochemist/protein crystallographer with 0-2 years of postdoctoral experience to work on the structural characterization of protein tyrosine phosphatases involved in T cell signaling regulation.

The project is a collaboration between the Bottini and the Zajonc laboratories at LIAI and the candidate should show a general interest in immunology/signal transduction. Experience in protein expression, purification, crystallization and structure determination is highly desired. The structural biology lab is well equipped with state of the art robotics and imaging systems (Art Robbins Phoenix, Rigaku Desktop Minstrel), a xray source (Oxford Diffraction XCalibur PX Ultra) and access to SSRL for remote data collection.

The position is available immediately and funded by the NIH for 2 years. Applications, including the name and addresses of 3 references can be directly sent to dzajonc@liai.org.

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Postdoctoral Position - University of Texas Medical School at Houston 

A postdoctoral position to study membrane protein structure
One postdoctoral position is available immediately at the Center for Membrane Biology, Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston. (http://www.uth.tmc.edu/cmb/)

The successful candidate will focus on a well-established membrane protein structural biology project. You will work on structural determination of an important ion transporter protein by x-ray crystallography. The protein expression and crystallization methods for this protein have been well-developed. You will be responsible to optimize the current crystallization conditions using standard membrane protein techniques and other novel optimization approaches developed in the laboratory. You will also have an opportunity to work with other expertise in the center to study its functional characterization. (Any request for the project details is welcome.)

The ideal applicant should be a self-motivated individual and have a recent PhD degree in structural biology, biochemistry or molecular biology. Strong background in protein crystallization and structural determination is expected.

The laboratory locates in Texas Medical Center campus which provides an excellent environment for academia and research. Our lab is fully equipped with all aspects of molecular biology, protein biochemistry and protein x-ray crystallography, including a Rigaku rotating anode X-ray home source and immediate access to the Berkeley ALS beamline 4.2.2 in the framework of the molecular biology consortium.

To apply, please send a current resume and the names and addresses of three referees to: Dr. Lei Zheng, Center for Membrane Biology, University of Texas HSC, 6431 Fannin St., Houston, TX 77030, USA. E-mail: lei.zheng@uth.tmc.edu

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Postdoctoral Position - European Molecular Biology Lab (EMBL)

The project aims at developing bioinformatics tools for a comprehensive validation of the low resolution SAXS models.  The work envisages a synergistic use of structural, biochemical and bioinformatics methods.  More information.

Dealdine for application: 8/31/10

Contact:

D.I. Svergun

EMBL c/o DESY

Notkestrasse 85

22607 Hamburg

Germany

tel: +49 40 89902 125

fax:+49 40 8992 149

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Postdoctoral Potisions (2) - Columbia Unviersity

Two Post-doctoral Research Associate positions are available for structural studies on enzymes involved in fatty acid metabolism or proteins involved in pre-mRNA 3'-end processing. We have extensive experience in these areas, and have produced many high-impact publications. Please see my home page for more information.

http://como.bio.columbia.edu/tong/

Strong experience in protein biochemistry is required. Prior experience with X-ray crystallography is desirable.  The successful candidates will be eligible for subsidized Columbia University housing. In addition to research in the laboratory, you will also be able to experience the excitement of New York City life, and have your own bite of the Big Apple.

Contact: Liang Tong

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Postdoctoral Research Associate - Children's National Medical Center

A Post-doctoral position in structural biology is available to train in structural biology of proteins of the urea cycle and arginine biosynthesis. The successful candidate will be mentored in generating and testing scientific hypotheses related to structural biology and biochemistry. He/she will work independently on projects under general guidance. Tasks will include design of study, collection and analysis of data, and reporting of results at symposia and in peer-reviewed manuscripts.

Ph.D. or equivalent doctoral degree in molecular biology or related field. Majors Preferred: Biology, Biochemistry, Structural Biology, Molecular Biology, Cell Biology or Microbiology.

2-3 years of related experience. Experience may have been obtained during doctoral training. Previous supervisory experience not required.

Experience in protein biochemistry and molecular biochemistry and molecular biology methods. Math proficiency and basic statistical skills. Basic UNIX skills. The following specific skills are preferred: construction of plasmids, transfection of cultured cells, gel electrophoresis, PCR analysis, protein purification, RNA and DNA purification, organelle fractionation, SDS/PAGE and Western blotting.

Please submit CV and 3 references.

Start Date: 10/1/10

Contact:

Dashuang Shi

111 Michigan Avenue

Washington, DC 20010

202-476-5817

dshi@cnmcresearch.org

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Postdoctoral Fellow in Protein Crystallography - Case Western Reserve University

A post-doctoral opening in protein crystallography in the laboratory of Chris Dealwis at Case Western Reserve University. The project involves structure determination of protein-protein complexes, and structure-based drug design. We are seeking for an individual that has a Ph.D in protein crystallography. Some basic biochemistry skills involving protein expression and purification will be extremely valuable. Candidates should send their CV to Chris Dealwis (cxd114@case.edu).

Contact:

Chris Dealwis, Ph.D. 
Department of Pharmacology
School of Medicine
Case Western Reserve University, 10900 Euclid Ave.
Cleveland, Ohio 44106-4965

cxd114@case.edu

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Postdoctoral Research Associate - EMBL

  The Panne laboratory at the EMBL seeks to recruit an outstanding postdoctoral scientist in structural biology. Our research focus is directed towards the structure of macromolecular assemblies involved in the innate immune system and in epigenetic gene regulation (Panne et al., Cell 2007; Panne, Current Opinion Structural Biology, 2008; Shen et al. Structure 2009).

The project focuses on the structural and biochemical characterization of regulatory complexes that are essential for the innate immune system. There are possibilities to participate in other ongoing exciting projects of high scientific impact. The laboratory is located on an international research campus in Grenoble providing one of the best structural biology environments in Europe. We employ a wide range of techniques including molecular biology, biochemistry, single-molecule fluorescence, electron microscopy, light scattering, X-ray crystallography and computing. Access to techniques such as automated expression and crystallization of proteins and protein complexes and to modern biophysical instrumentation is provided.

Candidates must hold (or soon expect to hold) a PhD in biochemistry, molecular biology, biophysics or related fields. This position requires experience in X-ray structure determination projects including phasing and knowledge in expressing and purifying proteins and/or protein complexes. The candidate should be a highly motivated individual who enjoys working as part of a collaborative and multidisciplinary team.

To apply, please email a cover letter, CV (in English) and contact information of three professional references quoting ref. no. W/10/PD/007 in the subject line, to application@embl.de.

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Postdoctoral Research Fellow - Membrane Proteins Structural Biology

Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo 

A post-doctoral position for an initial two years with possibility of extension is available in the laboratory of Dr. Preben Morth. The Postdoctoral position is funded by an NCMM grant and is available from the 1st of October. The Focus of the research will include membrane protein involved with osmoregualtion and anion transport in bacteria and higher eukaryotes. Projects focus on bicarbonate transport through the plasma membrane and the intra cellular complexes involved with their tight control.

NCMM, was established in 2007 as a partner institution of the European Molecular Biology Laboratory (www.embl.org ). NCMM is located in brand new laboratories in the University of Oslo and National Hospital Biomedical Campus in the Oslo Research Park and Preclinical Medicine buildings. A new Structural Biology laboratory at NCMM, headed by Dr. J. Preben Morth has been established, with focus in membrane proteins. This new laboratory is well equipped for a modern approach to structural biology, it include recombinant expression in bacterial and eukaryotic systems, new protein purification equipment and incubators. There is excellent synchrotron access to ESRF through the Norwegian bag proposal.

The University of Oslo has an in-house mass spectroscopy department for fast protein identification, facilities for electrophysiology and visualization equipment with electron microscopy and confocal microscopy.

Applicants must have a PhD, and should have extensive experience with Vector design and cloning in E. coli and baculovirus or yeast expression systems, protein purification and characterization. Experience with membrane proteins and protein crystallography will be an advantage but not necessary. A good command of English is required.

Oslo is a vibrant city in the south of Norway, with ready access to skiing in the winter and hiking in the summer. The Oslo bay and most of the coastline offer excellent scuba diving opportunities.

For more information, please see the NCMM home page: http://www.ncmm.uio.no
Please also refer to the regulations pertaining to the conditions of employment for post-doctoral fellowship positions:
http://www.uio.no/admhb/reglhb/personal/tilsettingvitenskapelig/regulationstermcondition.xml

Salary:
Postdoctoral Research Fellow (SKO, 1352), pay grade: 57 - 64 (NOK 448 200- 510 000 depending on experience and qualifications)

The application must include:
Application letter including a statement of interest, summarizing the applicant's scientific work and interests and describing how she/he fits the description of the person we seek
CV (summarizing education, positions, pedagogical experience, administrative experience and other qualifying activity), including a list of published and unpublished works
Copies of educational certificates, transcript of records, letters of recommendation
A complete list of publications and up to 5 academic works that the applicant wishes to be considered by the evaluation committee
Names and contact details of 2-3 references (name, relation to candidate, e-mail and telephone number)
Extended Applicant Form, to be filled in by the applicant
http://www.uio.no/om/jobb-ved-uio/ledige-stillinger/2010/vitenskapelige/sokerskjema_GBR.rtf

Closing date for applications: 15. August, 2010
The application should be sent electronically as a single pdf-file to recruitment@ncmm.uio.no labelled with Ref.no.: 2010/8649
The University of Oslo has an agreement for all employees, aiming to secure rights to research results a.o. The University of Oslo has a goal of recruiting more women in academic positions. Women are encouraged to apply. In accordance with the University of Oslo's equal opportunities policy, we invite applications from all interested individuals regardless of gender or ethnicity.

Contacts:
Requests for application information should be directed to CAO Elin Kaurstad E-mail: e.k.kaurstad@ncmm.uio.no
Requests for further information and inquiries regarding the post can be directed to Group Leader J.Preben Morth, PhD. E-mail: jpm@mb.au.dk

Please see the following URL for further details and guidelines for appointment to research fellowships at the University of Oslo:
http://www.matnat.uio.no/internt/administrasjonen/personal/Forskrifter-phd-postdoc-eng.pdf

The University of Oslo (UiO) wishes to achieve a more equal gender distribution of scientific staff. Female candidates are encouraged to apply.  UiO has an agreement for all employees, aiming to secure rights to research results a.o.

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Postdoctoral Position - Vanderbilt Univ., Nashville, TN

 Start Date: Immediately

An opening is available in the laboratory of Dr. Stephen Fesik (http://www.vicc.org/dd/display.php?id=4451) for a postdoc in the field of protein x-ray crystallography. Responsibilities will include protein expression/purification and all aspects of x-ray crystallography, including preparation of protein-inhibitor complexes, crystallization, home/synchrotron data collection, and structure determination. Experience in cloning, site-directed mutagenesis, and the use of crystallization robots is a plus. The ideal candidate should be self-motivated and be able to communicate effectively in a highly collaborative environment.  

Contact:  Jason Phan

Dept of Biochemistry

Vanderbilt University School of Medicine

Nashville, TN 37232

jason.phan@vanderbilt.edu

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Postdoc in Structural Biochemistry Oklahoma State University

A new postdoctoral fellow position is available immediately in the Department of Biochemistry and Molecular Biology, Oklahoma State University to study structure and function of protein complexes. Interested research areas include cytokine signaling, neurodegenerative diseases and innate immune system. Applicants should have a recent PhD in structural biology, biochemistry, molecular biology, cell biology or a related area. Good experiences in protein crystallography, protein expression and purification by using both E. coli and insect cell systems are expected.

More details at http://biochemistry.okstate.edu. Interested and motivated individuals should place inquiry directly to: junpeng.deng@okstate.edu. Please have three references sent directly to this email address as well.  

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 A fully funded postdoctoral position at Yale University School of Medicine is available immediately from highly motivated, enthusiastic individuals with a strong interest in the structure, function, and pharmacology of signaling proteins implicated in neurological and neuropsychiatric diseases. We are presently focusing our efforts on central nervous system transporters using a combination of steady-state kinetics, radioligand binding, and X-ray crystallography.

The laboratory is located in newly-renovated space in the Department of Cellular and Molecular Physiology in a highly collaborative environment. We have regular access to a Mosquito crystallization robot, an in-house X-ray diffractometer, LINUX workstations, and synchrotron beamlines.  The lab's proximity to the renowned W.M. Keck facility will additionally enable the successful candidate to conduct detailed experiments in static and dynamic light scattering, isothermal titration calorimetry, steady-state and stopped-flow fluorometry, and surface plasmon renonance.

Candidates must hold (or soon expect to hold) a Ph.D. in biochemistry, biophysics, or a related field. A strong background in recombinant DNA methods, protein expression and purification, and X-ray crystallography is required. Prior work with membrane proteins, tissue culture, and functional assays is preferred but not necessary. The ideal candidate will also possess excellent oral and written communication skills and work well in a collaborative environment.

For more information, please contact me via e-mail. Applicants may also be interested in reading the following review article:

Singh, S.K. (2008) LeuT: a prokaryotic stepping stone on the way to a eukaryotic neurotransmitter transporter structure. Channels. 2, 380-389

Applicants should send a CV, along with a one-page summary of previous research experience, and arrange to have 3 reference letters sent to Satinder K. Singh via e-mail at satinder.k.singh@yale.edu

Satinder K. Singh, Ph.D.

Assistant Professor of Cellular and Molecular Physiology

Yale University School of Medicine

333 Cedar Street, SHM B147

Lab room # SHM BE11/17

P.O. Box 208026

New Haven, CT 06520-8026

Office #: 203-737-4861

Fax #: 203-785-4951

E-mail: satinder.k.singh@yale.edu

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Postdoctoral Crystallographer - University of Alabama at Birmingham

Description:  to work on crystal structures of viral proteins

Location: Birmingham, AL

Start Date:  immediately

Contact:  Prof. Ming Luo

Univ. of Alabama at Birmingham

Birmingham, AL 35294

mingluo@uab.edu

(205) 934-4259

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 Postdoctoral Position - University of Wisconsin

Description:  The Computation and Informatics in Biology and Medicine training program invites applications for a structural scientist interested in the development and applications of new methods in solution and analysis of macromolecular structures. Candidates must be US citizens or permanent residents. Ph.D.required in Biophysics,Computer Science, Physics, Chemistry or related area.

Location:  Madison, WI

Start Date:  to be negotiated

Contact:  Dr. George Phillips

University of Wisconsin

Madison, WI, USA

phillips@biochem.wisc.edu

(608) 263 6142

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Postdoctoral Associate in Structural Biology - University of Colorado Denver School of Medicine

Description: A full-time position is available in the Department of Pharmacology, University of Colorado Denver School of Medicine to study molecular mechanisms underlying protein-protein interactions and to determine crystal structures of macromolecular complexes [http://pharmacology.ucdenver.edu/faculty/kutateladze].
Location:  Aurora, CO

Start Date:  October 2010

Contact:  Dr. Tatiana Kutateladze

Denver School of Medicine

University of Colorado

tatiana.kutateladze@ucdenver.edu

(303) 724-3593

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