Impact of Structural Science 

 

During the 20th century structural science advanced from the first crystal structures of sodium chloride and diamond to ever-larger structures: proteins such as hemoglobin, DNA, the ribosome, viruses, and even non-crystalline materials. During the century the technology to produce x-rays progressed from the first x-ray tubes to synchrotron radiation to free electron lasers, while computer hardware and software continued to make determining structures faster and more precise. The significance of these scientific discoveries - from biology to materials science - is reflected in the Nobel Prizes awarded in the area of structural science. These discoveries impact our economy, healthcare, and our everyday understanding of the natural world. 


"Timelines of Crystallography" 

Interactive displays of the many aspects of crystallography and structural science...more



"From Molecules to Medicine: How Structure Helps Cure Disease" 

Greg Petsko, moderated by Martha Teeter

In this YouTube video Dr. Petsko describes how structural information is used to design drugs against neurological diseases such as Alzheimer's...more



"The Protein Data Bank archive as an open data resource" 

Helen M. Berman, Gerard J. Kleywegt, Haruki Nakamura, John L. Markley, J Comput Aided Mol Des (2014) 28:1009-1014.

In 2016 there were over 125,000 structures in the PDB. Berman et al. describe the evolution of this valuable archive in the 45 years since the PDB was founded...>PDF


"History of NSLS - First Light to Shutdown"

Alison Sundermier and Vivian Stojanoff, ACA RefleXions, 2015:2, 47-52

The year was 1982. Brookhaven National Laboratory (BNL) in Upton, New York was celebrating a milestone at its newest facility: the National Synchrotron Light Source (NSLS) had achieved its first light...more